5-Chloroindole

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Names

[ CAS No. ]:
17422-32-1

[ Name ]:
5-Chloroindole

[Synonym ]:
5-Chloro-1H-indole
MFCD00005672
5-Chloroindole
1H-Indole, 5-chloro-
EINECS 241-448-9
5-Cl-indole
ChloroIndole
5-Chloro indole
1H-Indole,5-chloro

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
293.0±13.0 °C at 760 mmHg

[ Melting Point ]:
69-71 °C(lit.)

[ Molecular Formula ]:
C8H6ClN

[ Molecular Weight ]:
151.593

[ Flash Point ]:
158.9±5.4 °C

[ Exact Mass ]:
151.018875

[ PSA ]:
15.79000

[ LogP ]:
2.93

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.688

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Chloro-2-ethynylaniline
  • 5-Chloroindoline
  • 5-Chloroindole-2-carboxylic acid
  • 1-(tert-Butoxycarbonyl)-5-chloroindole
  • 4-chloro-2-((trimethylsilyl)ethynyl)aniline
  • 5-Bromoindole
  • Triethanolamine
  • 4-Chloroaniline
  • TRIETHANOLAMINE HYDROCHLORIDE
  • 4-Chloro-2-iodoaniline

DownStream

  • 5-chloro-3-[1-((imidazolidin-2-one-1-yl)-ethyl)-1,2,5,6-tetrahydropyridin-4-yl]-1-(4-fluorophenyl)-indole
  • (1-(TERT-BUTOXYCARBONYL)-5-CHLORO-1H-INDOL-2-YL)BORONIC ACID
  • 5-Chloroisatonic anhydride
  • 2-(5-Chloro-1H-indol-3-yl)ethanamine hydrochloride
  • 8-chloro-2-phenyl-5H-pyrazolo[3,4-c]quinolin-4-one
  • 5-chloro-3-phenyl-1H-indole
  • 5-chloro-2-piperazin-1-ylsulfonyl-1H-indole
  • TERT-BUTYL ((1H-INDOL-5-YL)METHYL)CARBAMATE
  • 1H-INDOLE-3-METHANAMINE, 5-CHLORO-N,N-DIMETHYL-
  • 5-Chloroindole-3-carboxaldehyde

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.

J. Med. Chem. 52 , 4694-715, (2009)

We describe a novel fragment library termed fragments of life (FOL) for structure-based drug discovery. The FOL library includes natural small molecules of life, derivatives thereof, and biaryl protei...

5-Chloroindole: a potent allosteric modulator of the 5-HT₃ receptor.

Br. J. Pharmacol. 169(6) , 1228-38, (2013)

The 5-HT₃ receptor is a ligand-gated ion channel that is modulated allosterically by various compounds including colchicine, alcohols and volatile anaesthetics. However the positive allosteric modulat...

Multicomponent phenol hydroxylase-catalysed formation of hydroxyindoles and dyestuffs from indole and its derivatives.

Lett. Appl. Microbiol. 41(2) , 163-8, (2005)

To establish multicomponent phenol hydroxylases (mPHs) as novel biocatalysts for producing dyestuffs and hydroxyindoles such as 7-hydroxyindole (7-HI) from indole and its derivatives.We have isolated ...


More Articles

Related Compounds

  • 1-BOC-5-Chloroindole
  • 3-bromo-5-chloroindole
  • 3-Bromo-5-chloroindole
  • 7-Bromo-5-chloroindole
  • 3-nitro-5-chloroindole
  • 7-Amino-5-chloroindole
  • 1-Amino-3,3-difluorocyclohexane-1-carboxylic acid
  • tert-Butyl 3-((methylamino)methyl)-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate
  • 3-(1,4-Dimethylpyrazol-3-yl)propanoic acid
  • 4-(3-Bromo-4-methylphenyl)butan-2-amine
  • (4-(Difluoromethoxy)cyclohexyl)methanamine
  • 4-(Cyclobutylmethyl)-1H-pyrrole-2-carboxylic acid
  • 4-Fluoro-2-(2-methylphenyl)pyrrolidine
  • 4-Fluoro-2-(4-methylphenyl)pyrrolidine
  • 4-Fluoro-2-(3-methylphenyl)pyrrolidine
  • 3-(3-Formyl-4-methoxyphenyl)prop-2-ynoic acid
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