β-Estradiol 17-acetate

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Names

[ CAS No. ]:
1743-60-8

[ Name ]:
β-Estradiol 17-acetate

[Synonym ]:
Cardene IV
Cardene SR
Beta-Estradiol 17-acetate
Nicardipino
estradiol 17-acetate
nicardipine
Nicardipine LA
Nicardipinum
β-Estradiol 17-acetate

Chemical & Physical Properties

[ Density]:
1.18g/cm3

[ Boiling Point ]:
450.5ºC at 760 mmHg

[ Molecular Formula ]:
C20H26O3

[ Molecular Weight ]:
314.41900

[ Flash Point ]:
181.9ºC

[ Exact Mass ]:
314.18800

[ PSA ]:
46.53000

[ LogP ]:
4.18000

[ Vapour Pressure ]:
9.88E-09mmHg at 25°C

[ Index of Refraction ]:
1.583

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H360

[ Precautionary Statements ]:
P201-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R60;R61

[ Safety Phrases ]:
S53-S45

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Estra-1,3,5(10)-trien-17-ol, 3-methoxy-, acetate, (17beta)-(+/-)-
  • beta-Estradiol
  • ethyl acetate
  • 19-Nortestosterone acetate
  • Ethanoic anhydride
  • 17β-Acetoxy-3-benzyloxyestra-1,3,5(10)-triene
  • 3-O-Benzyl Estradiol
  • Estrone
  • Estra-1,3,5(10),6-tetraene-3,17-diol, 17-acetate, (17β)

DownStream

  • [(8R,9S,13S,14S,17S)-13-methyl-3,4-dioxo-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] acetate
  • beta-Estradiol
  • 4-hydroxyestradiol
  • 17β-Estradiol 3-β-D-Glucuronide

Articles

Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats.

J. Neuroimmunol. , (2008)

Estrogen has been shown to attenuate the inflammatory response following injury or lipopolysaccharide treatment in several organ systems. Estrogen's actions are transduced through two estrogen recepto...

LCAT facilitates transacylation of 17 beta-estradiol in the presence of HDL3 subfraction.

J. Lipid Res. 43(3) , 392-7, (2002)

It has been shown that estrogens need to be metabolized to their hydrophobic estrogen ester derivatives to act as antioxidants in lipoproteins. Data suggest that 17beta-estradiol (E(2)) becomes esteri...

High-performance liquid chromatographic determination of 17beta-estradiol and 17beta-estradiol-3-acetate solubilities and diffusion coefficents in silicone elastromeric intravaginal rings.

J. Chromatogr. B. Biomed. Sci. Appl. 744(1) , 157-63, (2000)

A rapid, sensitive reversed-phase high-performance liquid chromatographic method has been developed for the determination of in vitro release of 17beta-estradiol and its ester prodrug, 17beta-estradio...


More Articles

Related Compounds

  • 17-β-estradiol 3-phosphate 17-acetate
  • (17a)-17-(Acetyloxy)-19-norpregna-1,3,5(10)-trien-20-yn-3-yl--D-Glucopyranosiduronic Acid Methyl Ester Triacetate
  • Estradiol Cypionate
  • Ethynylestradiol 17-Acetate
  • Estradiol valerate
  • estradiol 17-acetate
  • 4-BroMo-2-oxo-cyclohexanecarboxylic acid ethyl ester
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 1-ethyl-5-[(2,2,2-trifluoroethoxy)methyl]-1H-pyrazol-3-amine
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine