SB-222200

[ Density]:
1.142g/cm3

[ Boiling Point ]:
553.5ºC at 760 mmHg

[ Molecular Formula ]:
C₂₆H₂₄N₂O

[ Molecular Weight ]:
380.48200

[ Flash Point ]:
288.6ºC

[ Exact Mass ]:
380.18900

[ PSA ]:
41.99000

[ LogP ]:
6.48220

[ Vapour Pressure ]:
2.7E-12mmHg at 25°C

[ Index of Refraction ]:
1.633

[ Storage condition ]:
2-8℃

Click to get detail MSDS

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist.

J. Pharmacol. Exp. Ther. 295(1) , 373-81, (2000)

The pharmacological and pharmacokinetic profile of SB-222200 [(S)-(-)-N-(alpha-ethylbenzyl)-3-methyl-2-phenylquinoline-4-car boxami de], a human NK-3 receptor (hNK-3R) antagonist, was determined. SB-2...

In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists.

Br. J. Pharmacol. 122 , 469-476, (1997)

1. Inhibition of NK3 receptor agonist-induced contraction in the rabbit isolated iris sphincter muscle was used to assess the in vitro functional activity of three 2-phenyl-4-quinolinecarboxamides, me...

Expression of neurokinin B/NK3 receptor and kisspeptin/KISS1 receptor in human granulosa cells.

Hum. Reprod. 29(12) , 2736-46, (2014)

Are neurokinin B (NKB), NK3 receptor (NK3R), kisspeptin (KISS1) and kisspeptin receptor (KISS1R) expressed in human ovarian granulosa cells?The NKB/NK3R and kisspeptin/KISS1R systems are co-expressed ...

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