SB-222200

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Names

[ CAS No. ]:
174635-69-9

[ Name ]:
SB-222200

[Synonym ]:
Lopac-S-5192
Tocris-1393
SB-222200

Chemical & Physical Properties

[ Density]:
1.142g/cm3

[ Boiling Point ]:
553.5ºC at 760 mmHg

[ Molecular Formula ]:
C26H24N2O

[ Molecular Weight ]:
380.48200

[ Flash Point ]:
288.6ºC

[ Exact Mass ]:
380.18900

[ PSA ]:
41.99000

[ LogP ]:
6.48220

[ Vapour Pressure ]:
2.7E-12mmHg at 25°C

[ Index of Refraction ]:
1.633

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist.

J. Pharmacol. Exp. Ther. 295(1) , 373-81, (2000)

The pharmacological and pharmacokinetic profile of SB-222200 [(S)-(-)-N-(alpha-ethylbenzyl)-3-methyl-2-phenylquinoline-4-car boxami de], a human NK-3 receptor (hNK-3R) antagonist, was determined. SB-2...

In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists.

Br. J. Pharmacol. 122 , 469-476, (1997)

1. Inhibition of NK3 receptor agonist-induced contraction in the rabbit isolated iris sphincter muscle was used to assess the in vitro functional activity of three 2-phenyl-4-quinolinecarboxamides, me...

Expression of neurokinin B/NK3 receptor and kisspeptin/KISS1 receptor in human granulosa cells.

Hum. Reprod. 29(12) , 2736-46, (2014)

Are neurokinin B (NKB), NK3 receptor (NK3R), kisspeptin (KISS1) and kisspeptin receptor (KISS1R) expressed in human ovarian granulosa cells?The NKB/NK3R and kisspeptin/KISS1R systems are co-expressed ...


More Articles

Related Compounds

  • SB-200646A
  • SB-269970
  • SB-668875
  • SB 612111-d4 hydrochloride
  • SB-408124 Hydrochloride
  • SB 243213 hydrochloride
  • (R)-1-(1-(2-Fluorobenzyl)piperidin-3-yl)urea hydrochloride
  • 3-Ethyl-7-methoxy-5,8-dimethyl-[1,2,4]triazolo[4,3-c]pyrimidine
  • Dihydro-2'H-8-azaspiro[bicyclo[3.2.1]octane-3,3'-furan]
  • 8-Azaspiro[bicyclo[3.2.1]octane-3,4'-piperidine]
  • 4-Hydroxypicolinic acid hydrochloride
  • 5-Bromo-6-chloro-1H-indole-3-sulfonyl chloride
  • 4,4-Dimethyl-1-oxaspiro[2.4]heptane-2-carbonitrile
  • Tetrasodium (8-hydroxy-7-((2-hydroxy-7-sulpho-6-((4-((2,5,6-trichloro-4-pyrimidinyl)amino)phenyl)azo)-1-naphthyl)azo)naphthalene-1,3,6-trisulphonato(6-))cuprate(4-)
  • (Ethoxyethane)[tris(pentafluorophenyl)]boron
  • 2-(Piperidin-1-yl)ethyl (cyclohepta-2,4,6-trien-1-yl)acetate--hydrogen chloride (1/1)
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