Mast Cell Degranulating (MCD) Peptide
Suppliers
Names
[ CAS No. ]:
17466-45-4
[ Name ]:
Mast Cell Degranulating (MCD) Peptide
[Synonym ]:
EINECS 241-484-5
MFCD03427567
PHALLOIDIN
Phalloidine
28-(2,3-dihydroxy-2-methylpropyl)-18-hydroxy-34-(1-hydroxyethyl)-23,31-dimethyl-12-thia-10,16,22,25,27,30,33,36-octaazapentacyclo[12.11.11.03,11.04,9.016,20]hexatriaconta-3(11),4,6,8-tetraene-15,21,24,26,29,32,35-heptone
Phalloidin from Amanita phalloides
Cyclic(L-alanyl-D-threonyl-L-cysteinyl-cis-4-hydroxy-L-prolyl-L-alanyl-2-mercapto-L-tryptophyl-4,5-dihydroxy-L-leucyl),cyclic (3,6)-sulfide
Chemical & Physical Properties
[ Density]:
1.51g/cm3
[ Boiling Point ]:
1370.5ºC at 760mmHg
[ Molecular Formula ]:
C35H48N8O11S
[ Molecular Weight ]:
788.86800
[ Flash Point ]:
782.6ºC
[ Exact Mass ]:
788.31600
[ PSA ]:
316.92000
[ Vapour Pressure ]:
0mmHg at 25°C
[ Index of Refraction ]:
1.683
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SE9800000
- CHEMICAL NAME :
- Phalloidin
- CAS REGISTRY NUMBER :
- 17466-45-4
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C35-H48-N8-O11-S
- MOLECULAR WEIGHT :
- 788.97
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6600 ug/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness Liver - fatty liver degeneration
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 1000 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - rat Liver
- DOSE/DURATION :
- 100 nmol/L
- REFERENCE :
- TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 25,1265,1987
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H300 + H310 + H330
[ Precautionary Statements ]:
P260-P264-P280-P284-P301 + P310-P302 + P350
[ Hazard Codes ]:
T+
[ Risk Phrases ]:
26/27/28
[ Safety Phrases ]:
S22;S28;S45;S36/S37
[ RIDADR ]:
UN 3462 6.1/PG 2
[ RTECS ]:
SE9800000
[ Hazard Class ]:
6.1(a)
Precursor & DownStream
Precursor
DownStream
Articles
Biochemistry 52(9) , 1611-21, (2013)
Myosin powers contraction in heart and skeletal muscle and is a leading target for mutations implicated in inheritable muscle diseases. During contraction, myosin transduces ATP free energy into the w...
Biochim. Biophys. Acta 1838(10) , 2607-14, (2014)
A diminution in the order of membrane lipids, which occurs during apoptosis, has been shown to correlate with increased membrane susceptibility to hydrolysis by secretory phospholipase A2. Studies wit...
Proc. Natl. Acad. Sci. U. S. A. 105(44) , 16882-7, (2008)
Many proteins have been shown to undergo conformational changes in response to externally applied force in vitro, but whether the force-induced protein conformational changes occur in vivo remains unc...