2-Phenoxyethanamine

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Names

[ CAS No. ]:
1758-46-9

[ Name ]:
2-Phenoxyethanamine

[Synonym ]:
2-Phenoxyethanamine
4-Aminophenetole
p-Phenetidine
EINECS 217-153-6
2-Phenoxy-ethylamine
Ethanamine, 2-phenoxy-
Phenetidine
MFCD00052975
4-Ethoxyaniline
2-phenoxyethylamino

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
230.3±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C8H11NO

[ Molecular Weight ]:
137.179

[ Flash Point ]:
97.9±15.9 °C

[ Exact Mass ]:
137.084061

[ PSA ]:
35.25000

[ LogP ]:
0.89

[ Vapour Pressure ]:
0.1±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.527

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KR9500000
CHEMICAL NAME :
Ethylamine, 2-phenoxy-
CAS REGISTRY NUMBER :
1758-46-9
BEILSTEIN REFERENCE NO. :
0774671
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C8-H11-N-O
MOLECULAR WEIGHT :
137.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
95 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - central sympatholytic Vascular - BP lowering not characterized in autonomic section
REFERENCE :
85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,172,1948

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2735 8/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
KR9500000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2922299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • phenoxyacetamide
  • 2-(2-phenoxyethyl)-1H-isoindole-1,3(2H)-dione
  • 2-azidoethoxybenzene
  • oxazolidinone
  • Phenol
  • Phenoxyacetonitrile
  • Phenoxyethanol
  • Aziridine
  • β-Bromophenetole
  • 2-Phenoxyethyl 4-methylbenzenesulfonate

DownStream

  • 2-phenoxyethanamine,hydrochloride
  • N-(2-Phenoxyethyl)trimethylsilylamine
  • tert-butyl N-(2-phenoxyethyl)carbamate
  • Benzenamine, N- (2-phenoxyethyl)-
  • tert-butyl N-methyl-N-(2-phenoxyethyl)carbamate

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Dynamic nuclear polarization with polychlorotriphenylmethyl radicals: supramolecular polarization-transfer effects.

Angew. Chem. Int. Ed. Engl. 49(19) , 3360-2, (2010)

Syntheses of 1,4-benzothiazepines and 1,4-benzoxazepines via cyclizations of 1-[2-arylthio(oxy)ethyl]-5-benzotriazolyl-2-pyrrolidinones and 3-benzotriazolyl-2-[2-arylthio(oxy)ethyl]-1-isoindolinones.

J. Org. Chem. 66(16) , 5590-4, (2001)

1-[2-Arylthio(oxy)ethyl]-5-benzotriazolyl-2-pyrrolidinones 6a-e, 12 and 3-benzotriazolyl-2-[2-arylthio(oxy)ethyl]-1-isoindolinones 9a-f, 14 are readily available from reactions of benzotriazole (4), 2...

Stable gaseous aziridinium ions. Van de Sande CC, et al.

Org. Mass Spectrom. 13(11) , 666-70, (1978)


More Articles

Related Compounds

  • 2-Phenoxyethanamine
  • N-ethyl-2-phenoxyethanamine
  • N-methyl-2-phenoxyethanamine
  • 2-Methoxy-2-phenoxyethanamine
  • N,N-Diethyl-2-phenoxyethanamine
  • N,N-Dimethyl-2-phenoxyethanamine