7-chloro-5-(2-fluorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one

Names

[ CAS No. ]:
17617-60-6

[ Name ]:
7-chloro-5-(2-fluorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one

[Synonym ]:
Ro 7-5205
3-Hydroxy-N-desalkyl-2-oxoquazepam
OX 164F

Chemical & Physical Properties

[ Density]:
1.48g/cm3

[ Boiling Point ]:
507.1ºC at 760mmHg

[ Molecular Formula ]:
C15H10ClFN2O2

[ Molecular Weight ]:
304.70400

[ Flash Point ]:
260.5ºC

[ Exact Mass ]:
304.04100

[ PSA ]:
61.69000

[ LogP ]:
2.16060

[ Vapour Pressure ]:
4.18E-11mmHg at 25°C

[ Index of Refraction ]:
1.668

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DF2370105
CHEMICAL NAME :
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(o-fluorophenyl)-3-hydroxy-
CAS REGISTRY NUMBER :
17617-60-6
BEILSTEIN REFERENCE NO. :
0759083
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C15-H10-Cl-F-N2-O2
MOLECULAR WEIGHT :
304.72

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
774 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 12,74,1974

Synthetic Route

Click to get detail synthetic route

Related Compounds

  • methyl (3R)-3-(2,2-dimethyl-1,1-dioxo-1lambda6-thiolan-3-yl)-3-hydroxypropanoate
  • 1,1,1-Trifluoro-4,4-dimethoxybutan-2-ol
  • 4-(2-chloro-6-methylphenyl)-1H-imidazole
  • 4-Methyl-3-(4-methyl-1,3-thiazol-2-yl)cyclohexan-1-amine
  • Methyl 3-(2,2-dimethyl-1,1-dioxo-1lambda6-thiolan-3-yl)-3-hydroxypropanoate
  • 5-ethynyl-N,N-dimethyl-1,3-thiazol-2-amine
  • 3-(3,5-Difluoro-2-methoxyphenyl)prop-2-en-1-ol
  • 3-[(2R,3S)-3-(benzyloxy)-N-(cyclopropylmethyl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]propanoic acid
  • 4-{[1-benzyl-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pyrrolidin-3-yl]formamido}but-2-ynoic acid
  • (2S,3R)-3-(tert-butoxy)-2-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)but-2-ynamido]butanoic acid
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