Bisindolylmaleimide I HCl

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Names

[ Name ]:
Bisindolylmaleimide I HCl

[Synonym ]:
Bisindolylmaleimide I,HCl
Bisindolylmaleimide I
3-[1-(Dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride
Go-6850
BIM I
Bisindolylmaleimide I hydrochloride
Bisindolylmaleimide
2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide,HCl

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₅ClN₄O₂

[ Molecular Weight ]:
448.94500

[ Exact Mass ]:
448.16700

[ PSA ]:
73.62000

[ LogP ]:
4.71940

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Protein kinase C-mediated phosphorylation of a single serine residue on the rat glial glutamine transporter SN1 governs its membrane trafficking.

J. Neurosci. 31 , 6565-75, (2011)

Molecular mechanisms involved in the replenishment of the fast neurotransmitters glutamate and GABA are poorly understood. Glutamine sustains their generation. However, glutamine formation from the re...

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.

J. Biol. Chem. 266 , 15771, (1991)

Staurosporine is the most potent inhibitor of protein kinase C (PKC) described in the literature with a half-maximal inhibitory concentration (IC50) of 10 nM. Nevertheless, this natural product is poo...

PDGF receptor activation induces p120-catenin phosphorylation at serine 879 via a PKCalpha-dependent pathway.

Exp. Cell Res. 315 , 39-49, (2009)

p120-catenin (p120) is required for cadherin stability and is thought to have a central role in modulating cell-cell adhesion. Several lines of evidence suggest that S/T phosphorylation may regulate p...

Bisindolylmaleimide I (GF109203X)
Ro 31-8220
Bisindolylmaleimide X HCl
Bisindolylmaleimide II
3-[8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione
Bisindolylmaleimide XI hydrochloride
1-Benzhydryl-3-((1-(pyridin-2-yl)piperidin-4-yl)methyl)urea
2-((1-(4-(difluoromethoxy)phenyl)-5-(4-methoxyphenyl)-1H-imidazol-2-yl)thio)-N-(4-methylthiazol-2-yl)acetamide
N-((1-(pyrimidin-2-yl)piperidin-4-yl)methyl)cyclobutanecarboxamide
N-((1-(pyrimidin-2-yl)piperidin-4-yl)methyl)pyrazine-2-carboxamide
2-((1-(4-(difluoromethoxy)phenyl)-5-(4-methoxyphenyl)-1H-imidazol-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide
(E)-3-(furan-2-yl)-N-((1-(pyrimidin-2-yl)piperidin-4-yl)methyl)acrylamide
2,5-dimethyl-N-((1-(pyrimidin-2-yl)piperidin-4-yl)methyl)furan-3-carboxamide
4-methyl-N-((1-(pyrimidin-2-yl)piperidin-4-yl)methyl)thiophene-2-carboxamide
4-methyl-N-((1-(pyrimidin-2-yl)piperidin-4-yl)methyl)-1,2,3-thiadiazole-5-carboxamide
3,4-Dimethoxyphenyl-(1-methyl-2-pyrrolyl)methanol

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