(R,S)-Norcotinine

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Names

[ Name ]:
(R,S)-Norcotinine

[Synonym ]:
Demethylcotinine
5-(pyridin-3-yl)-pyrrolidin-2-one
(R,S)-Norcotinine
(+-)-5-[3]pyridyl-pyrrolidin-2-one
5-(3-Pyridinyl)-2-pyrrolidinone
5-(pyridin-3-yl)pyrrolidin-2-one
(+-)-5-[3]Pyridyl-pyrrolidin-2-on
2-Pyrrolidinone, 5-(3-pyridinyl)-
norcotinine

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
398.2±35.0 °C at 760 mmHg

[ Melting Point ]:
108-109ºC

[ Molecular Formula ]:
C₉H₁₀N₂O

[ Molecular Weight ]:
162.189

[ Flash Point ]:
194.6±25.9 °C

[ Exact Mass ]:
162.079315

[ PSA ]:
41.99000

[ LogP ]:
-1.00

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.554

[ Storage condition ]:
-20°C Freezer, Under Inert Atmosphere

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Hazard Codes ]:
F,T

[ Risk Phrases ]:
11-23/24/25-39/23/24/25

[ Safety Phrases ]:
16-36/37-45

[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Determination of nicotine and four metabolites in the serum of smokers by high-performance liquid chromatography with ultraviolet detection.

J. Chromatogr. A. 621(2) , 257-61, (1993)

A simple and reliable reversed-phase high-performance liquid chromatographic method with ultraviolet detection is described for the quantitation of nicotine and its metabolites cotinine, trans-3'-hydr...

Meconium nicotine and metabolites by liquid chromatography-tandem mass spectrometry: differentiation of passive and nonexposure and correlation with neonatal outcome measures.

Clin. Chem. 54(12) , 2018-27, (2008)

Meconium analysis is a diagnostically sensitive and objective alternative to maternal self-report for detecting prenatal tobacco exposure. Nicotine and metabolite disposition in meconium is poorly cha...

Quantification of nicotine, cotinine, trans-3'-hydroxycotinine, nornicotine and norcotinine in human meconium by liquid chromatography/tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 863(1) , 107-14, (2008)

There are no analytical methods that simultaneously quantify nicotine, cotinine, trans-3'-hydroxycotinine, nornicotine and norcotinine in human meconium. Such a method could improve identification of ...

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