N-(4-Ethoxy-3-nitrophenyl)acetamide

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Names

[ CAS No. ]:
1777-84-0

[ Name ]:
N-(4-Ethoxy-3-nitrophenyl)acetamide

[Synonym ]:
Essigsaeure-(4-aethoxy-3-nitro-anilid)
acetic acid-(4-ethoxy-3-nitro-anilide)
5-Nitro-p-acetophenetidide
Acetamide,N-(4-ethoxy-3-nitrophenyl)
3'-Nitro-p-acetophenetidin
4-ethoxy-3-nitroacetanilide
4-Acetamino-2-nitrophenetole
3-Nitro-p-acetophenetide
2-Nitro-4-acetamino-phenetol
p-Acetophenetidide,3'-nitro

Chemical & Physical Properties

[ Density]:
1.282g/cm3

[ Boiling Point ]:
429.6ºC at 760 mmHg

[ Melting Point ]:
123ºC

[ Molecular Formula ]:
C10H12N2O4

[ Molecular Weight ]:
224.21300

[ Flash Point ]:
213.6ºC

[ Exact Mass ]:
224.08000

[ PSA ]:
87.64000

[ LogP ]:
3.12460

[ Vapour Pressure ]:
1.38E-07mmHg at 25°C

[ Index of Refraction ]:
1.582

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AM4550000
CHEMICAL NAME :
p-Acetophenetidide, 3-nitro-
CAS REGISTRY NUMBER :
1777-84-0
BEILSTEIN REFERENCE NO. :
2735844
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C10-H12-N2-O4
MOLECULAR WEIGHT :
224.24
WISWESSER LINE NOTATION :
WNR BO2 EMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
957 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
478 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
1 mg/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5(Suppl 1),3,1983

Safety Information

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Phenacetin
  • Sulfuric acid

DownStream

  • 4-AMINO-2-NITROPHENETOLE
  • N-(3-amino-4-ethoxyphenyl)acetamide

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • N-(4-Chloro-3-nitrophenyl)acetamide
  • N-(4-butyl-3-nitrophenyl)acetamide
  • N-(4-ethyl-3-nitrophenyl)acetamide
  • N-(4-iodo-3-nitrophenyl)acetamide
  • N-(4-ethoxy-3,6-dioxocyclohexa-1,4-dien-1-yl)acetamide
  • N-(4-ethoxy-3,6-dihydro-2H-pyridin-1-yl)benzamide
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • 1-(2,4-Dimethylphenyl)-4-({1-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]piperidin-4-yl}carbonyl)piperazine
  • tert-Butyl-DL-alanine
  • Methyl 3-amino-2-(4-methylphenyl)propanoate hydrochloride