4-(Methylthio)acetophenone

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Names

[ CAS No. ]:
1778-09-2

[ Name ]:
4-(Methylthio)acetophenone

[Synonym ]:
4-(Acetyl)thioanisole
4‘-(Methylthio)acetophenone
EINECS 217-213-1
4-Methylmercaptoacetophenone
1-[4-(Methylsulfanyl)phenyl]ethanone
4-(Methylthio)acetophenone
p-methylthioacetophenone
4'-Methylthioacetophenone
MFCD00039835
1-(4-(Methylthio)phenyl)ethan-1-one
Ethanone, 1-[4-(methylthio)phenyl]-

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
282.5±23.0 °C at 760 mmHg

[ Melting Point ]:
80-82 °C(lit.)

[ Molecular Formula ]:
C9H10OS

[ Molecular Weight ]:
166.240

[ Flash Point ]:
140.7±8.3 °C

[ Exact Mass ]:
166.045242

[ PSA ]:
42.37000

[ LogP ]:
2.51

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.563

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Thioanisole
  • Acetyl chloride
  • Ethanoic anhydride
  • 1-(4-Methanesulfinylphenyl)ethan-1-one
  • 4-(Methylsulfanyl)benzonitrile
  • 2-O-ACETYL-MALIC ANHYDRIDE
  • Dimethyl disulfide
  • 1-(4-Bromophenyl)ethanone
  • Trimethyl(methylsulfanyl)silane

DownStream

  • 2-(4-methylsulfanylphenyl)-1-morpholin-4-ylethanethione
  • 4-Methylsulfonyl benzoic acid
  • 4-(Methylthio)benzaldehyde
  • 4-Methylsulfonyl phenyl acetic acid
  • 4'-METHYLTHIO-2-BROMOACETOPHENONE
  • 2-Bromo-1-[4-(methylsulfonyl)phenyl]ethanone
  • [2-(4-methylsulfonylphenyl)-2-oxoethyl] 2-phenylacetate
  • 2-(p-Methylthiophenyl)imidazo(1,2-a)pyridine
  • Enoximone
  • METHYL 1-(4-(TRIFLUOROMETHYL)PHENYL)-5-(4-(METHYLTHIO)PHENYL)-1H-PYRAZOLE-3-CARBOXYLATE

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Experimental and theoretical analysis of Friedel-Crafts acylation of thioanisole to 4-(methylthio) acetophenone using solid acids. Yadav GD and Bhagat RD.

J. Mol. Catal. A: Chem. 235(1) , 98-107., (2005)

(E)-1-[4-(Methylsulfanyl) phenyl]-3-phenylprop-2-en-1-one. Thiruvalluvar A, et al.

Acta Crystallogr. Sect. E Struct. Rep. Online 64(7) , o1263, (3008)

Liquid phase acetylation of thioanisole with acetic anhydride to 4-(methylthio) acetophenone (4-MTAP) using H-beta catalyst. Sawant DP and Halligudi SB.

Catal. Commun. 5(11) , 659-663, (2004)


More Articles

Related Compounds

  • 4-(methylthio)phenyl isothiocyanate
  • 4-methylthio-3,3,4-triphenyl-2-thietanone
  • 4-(METHYLTHIO)-2-(4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL)BUTANOIC ACID
  • 4-(methylthio)-1H-imidazo[4,5-c]pyridine
  • 4-(Methylthio)benzaldehyde
  • 4-(Methylthio)-1,3-benzothiazol-2-amine