Fenclozic acid

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Names

[ Name ]:
Fenclozic acid

[Synonym ]:
Mialex
UNII-58SRQ4DV53
Fenclozic acid
Acido fenclozico [Italian]
Acidum fenclozicum
[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid
4-Thiazoleacetic acid, 2-(4-chlorophenyl)-
MFCD00721754
Acide fenclozique [INN-French]
2-(2-(4-chlorophenyl)-2-thiazol-4-yl)acetic acid
Acido fenclozico [INN-Spanish]
acido fenclozico
Myalex
2-(4-chlorophenyl)-thiazol-4-yl acetic acid
2-(2-(4-chlorophenyl)thiazol-4-yl)acetic acid

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
444.7±55.0 °C at 760 mmHg

[ Melting Point ]:
150-152ºC

[ Molecular Formula ]:
C₁₁H₈ClNO₂S

[ Molecular Weight ]:
253.705

[ Flash Point ]:
222.8±31.5 °C

[ Exact Mass ]:
252.996429

[ PSA ]:
78.43000

[ LogP ]:
3.29

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.635

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ1800000

CHEMICAL NAME :: 4-Thiazoleacetic acid, 2-(p-chlorophenyl)-

CAS REGISTRY NUMBER :: 17969-20-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C11-H8-Cl-N-O2-S

MOLECULAR WEIGHT :: 253.71

WISWESSER LINE NOTATION :: T5N CSJ BR DG& E1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 221,582,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 221,582,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 40,875,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 40,875,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 221,582,1969 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 50 mg/kg

SEX/DURATION :: female 20-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - stillbirth

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 240,37,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 200 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 19,129,1979

Safety Information

[ Hazard Codes ]:
Xn

[ HS Code ]:
2934100090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934100090

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Related Compounds

Ethyl fenclozic acid
Octanethioic acid S-propyl ester
Hexanethioic acid S-decyl ester
Thiopropionic acid S-undecyl ester
trisporic acid
Benzenesulfonic acid, 3,3-methylenebis2,4(or 4,6)-dihydroxyphenyleneazobis-, potassium sodium salt
4-(iso-Propylphenyl-d11)-boronic acid
3-{[1,2,4]Triazolo[4,3-a]pyridin-3-yl}propan-1-amine hydrochloride
3-amino-N-(2-hydroxyethyl)benzamide hydrochloride
5-methyl-2-(piperidin-3-yl)-1H-1,3-benzodiazole dihydrochloride
N-(2-aminoethyl)-2H-indazole-3-carboxamide hydrochloride
Methyl 3-[(2-amino-1,3-thiazol-5-yl)methyl]benzoate hydrochloride
sodium 2-(4-methyl-5-phenyl-4H-1,2,4-triazol-3-yl)acetate
1-(5-Methylfuran-2-carbonyl)piperazine hydrochloride
Methyl 4-({[1-(ethanesulfonyl)piperidin-4-yl]carbamoyl}amino)benzoate
4-{[Cyclopropyl(ethyl)amino]methyl}benzoic acid hydrochloride

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