Fenclozic acid

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Names

[ CAS No. ]:
17969-20-9

[ Name ]:
Fenclozic acid

[Synonym ]:
Mialex
UNII-58SRQ4DV53
Fenclozic acid
Acido fenclozico [Italian]
Acidum fenclozicum
[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid
4-Thiazoleacetic acid, 2-(4-chlorophenyl)-
MFCD00721754
Acide fenclozique [INN-French]
2-(2-(4-chlorophenyl)-2-thiazol-4-yl)acetic acid
Acido fenclozico [INN-Spanish]
acido fenclozico
Myalex
2-(4-chlorophenyl)-thiazol-4-yl acetic acid
2-(2-(4-chlorophenyl)thiazol-4-yl)acetic acid

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
444.7±55.0 °C at 760 mmHg

[ Melting Point ]:
150-152ºC

[ Molecular Formula ]:
C11H8ClNO2S

[ Molecular Weight ]:
253.705

[ Flash Point ]:
222.8±31.5 °C

[ Exact Mass ]:
252.996429

[ PSA ]:
78.43000

[ LogP ]:
3.29

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.635

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ1800000
CHEMICAL NAME :
4-Thiazoleacetic acid, 2-(p-chlorophenyl)-
CAS REGISTRY NUMBER :
17969-20-9
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C11-H8-Cl-N-O2-S
MOLECULAR WEIGHT :
253.71
WISWESSER LINE NOTATION :
T5N CSJ BR DG& E1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
850 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 221,582,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 221,582,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 40,875,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 40,875,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 221,582,1969 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
50 mg/kg
SEX/DURATION :
female 20-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - stillbirth
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 240,37,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
200 mg/kg
SEX/DURATION :
male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 19,129,1979

Safety Information

[ Hazard Codes ]:
Xn

[ HS Code ]:
2934100090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-(4-Chlorophenyl)-4-thiazoleethanol

DownStream

  • 2-(4-Chlorophenyl)-4-thiazoleethanol

Customs

[ HS Code ]: 2934100090

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Related Compounds

  • Ethyl fenclozic acid
  • Octanethioic acid S-propyl ester
  • Hexanethioic acid S-decyl ester
  • Thiopropionic acid S-undecyl ester
  • trisporic acid
  • Benzenesulfonic acid, 3,3-methylenebis2,4(or 4,6)-dihydroxyphenyleneazobis-, potassium sodium salt
  • 3-(azetidin-3-yl)-4-[(2,6-difluorophenyl)methyl]-5-methyl-4H-1,2,4-triazole
  • 4-[3-Amino-2-(chloromethyl)propoxy]-5-fluoropyrimidine
  • dimethyl({2-[3-methyl-5-(pyrrolidin-3-yl)-4H-1,2,4-triazol-4-yl]ethyl})amine
  • 4-butyl-3-methyl-5-(pyrrolidin-3-yl)-4H-1,2,4-triazole
  • 1-(3-methoxypyridin-2-yl)-1H-indazol-4-amine
  • 4-[(4-fluorophenyl)methyl]-3-methyl-5-(pyrrolidin-3-yl)-4H-1,2,4-triazole
  • 1-(isoquinolin-4-yl)-1H-indazol-4-amine
  • 3-((3-Methyl-5-(pyrrolidin-3-yl)-4H-1,2,4-triazol-4-yl)methyl)pyridine
  • (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-6-methyl-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid
  • 4-(3-methoxypropyl)-3-methyl-5-(pyrrolidin-3-yl)-4H-1,2,4-triazole