Pregn-4-ene-3,20-dione,17,21-bis(acetyloxy)-

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Names

[ CAS No. ]:
1807-15-4

[ Name ]:
Pregn-4-ene-3,20-dione,17,21-bis(acetyloxy)-

[Synonym ]:
17,21-diacetoxy-4-pregnene-3,20-dione
Pregn-4-ene-3,20-dione,17,21-dihydroxy-,diacetate
17,21-Diacetoxyprogesterone
EINECS 217-307-2
17,21-Dihydroxypregn-4-ene-3,20-dione diacetate

Chemical & Physical Properties

[ Density]:
1.19g/cm3

[ Boiling Point ]:
543.8ºC at 760 mmHg

[ Molecular Formula ]:
C25H34O6

[ Molecular Weight ]:
430.53400

[ Flash Point ]:
232.8ºC

[ Exact Mass ]:
430.23600

[ PSA ]:
86.74000

[ LogP ]:
3.95240

[ Vapour Pressure ]:
6.92E-12mmHg at 25°C

[ Index of Refraction ]:
1.543

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU5014000
CHEMICAL NAME :
Pregn-4-ene-3,20-dione, 17,21-dihydroxy-, diacetate
CAS REGISTRY NUMBER :
1807-15-4
BEILSTEIN REFERENCE NO. :
2193141
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C25-H34-O6
MOLECULAR WEIGHT :
430.59

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
1 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press, 1965 Volume(issue)/page/year: -,57,1965

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 21-bromo-17α-hydroxypregn-4-ene-3,20-dione 17-acetate
  • reichstein's substance s 21-acetate
  • Ethanoic anhydride
  • Cortodoxone
  • 17-acetoxy-17β-ethynylandrost-4-en-3-one
  • 21,21-diiodo-17α-hydroxypregn-4-ene-3,20-dione 17-acetate
  • 17α-hydroxyprogesterone
  • Tetrabutylammonium Acetate

DownStream

  • 6alpha-Fluoroprednisolone acetate
  • Cortodoxone

Related Compounds

  • 9-Bromo-11,17,21-trihydroxypregn-4-ene-3,20-dione17,21-diacetate
  • Pregn-4-ene-3,20-dione, 17,21-dihydroxy-, (8ξ,9ξ,10ξ,13ξ,14ξ,17ξ)
  • Pregn-4-ene-3,20-dione, 17-(acetyloxy)-7-azido-6-bromo-, (6β,7α)
  • Pregn-4-ene-3,20-dione,17-(acetyloxy)-4-hydroxy- (9CI)
  • Pregn-4-ene-3,20-dione,17-(acetyloxy)-6-methyl-, (6b)- (9CI)
  • Pregn-4-ene-3,20-dione,17-(acetyloxy)-6-(trifluoromethyl)-, (6a)- (9CI)