8-methylcoumarin

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Names

[ CAS No. ]:
1807-36-9

[ Name ]:
8-methylcoumarin

[Synonym ]:
COUMARIN,8-METHYL
8-Methyl-2H-1-benzopyran-2-one
8-methyl-chromen-2-one
8-methyl-2H-chromen-2-one
2H-1-Benzopyran-2-one,8-methyl
8-Methylcoumarin
8-Methyl-cumarin

Chemical & Physical Properties

[ Density]:
1.2g/cm3

[ Boiling Point ]:
302.4ºC at 760 mmHg

[ Molecular Formula ]:
C10H8O2

[ Molecular Weight ]:
160.16900

[ Flash Point ]:
123.3ºC

[ Exact Mass ]:
160.05200

[ PSA ]:
30.21000

[ LogP ]:
2.10140

[ Vapour Pressure ]:
0.000994mmHg at 25°C

[ Index of Refraction ]:
1.583

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GN7792200
CHEMICAL NAME :
Coumarin, 8-methyl-
CAS REGISTRY NUMBER :
1807-36-9
BEILSTEIN REFERENCE NO. :
0121434
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H8-O2
MOLECULAR WEIGHT :
160.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
289 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 76,186,1956

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-Methylsalicylaldehyde
  • Ethanoic anhydride
  • Sodium acetate
  • Ethoxyethyne
  • o-cresol
  • methyl 3-(2-hydroxy-3-methylphenyl)-3-((3-methoxy-3-oxopropyl)thio)propanoate

DownStream

  • 3-AMINO-3-(2-HYDROXY-3-METHYL-PHENYL)-PROPIONIC ACID

Related Compounds

  • 7-methoxy-8-methylcoumarin
  • 4-hydroxy-8-methylcoumarin
  • 4,7-dihydroxy-8-methylcoumarin
  • l)oxy)-4-hydroxy-8-methylcoumarin)
  • 3-cyano-4-hydroxy-8-methylcoumarin
  • 4-hydroxy-7-methoxy-8-methylcoumarin
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 6-(1H-pyrazol-1-yl)hexan-2-amine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide