Bromodiphenhydramine hydrochloride
Suppliers
Names
[ CAS No. ]:
1808-12-4
[ Name ]:
Bromodiphenhydramine hydrochloride
[Synonym ]:
[2-(4-Brom-benzhydryloxy)-aethyl]-dimethyl-amin,Hydrochlorid
Bromdiphenhydramine hydrochloride
Bromdiphenylhydramine hydrochloride
Bromodiphenhydramine hydrochloride
2-[(4-bromophenyl)phenylmethoxy]ethyl(dimethyl)ammonium chloride
phenyl(p-bromophenyl)(dimethylaminoethoxy)methane hydrochloride
2-[(4-bromophenyl)-phenylmethoxy]ethyl-dimethylazanium,chloride
Bromazine hydrochloride
2-[(4-bromophenyl)phenylmethoxy]-N,N-dimethyl-ethanamine,hydrochloride
[2-(4-bromo-benzhydryloxy)-ethyl]-dimethyl-amine,hydrochloride
EINECS 217-310-9
Bromodiphenhydramine HCl
Chemical & Physical Properties
[ Boiling Point ]:
397.3ºC at 760 mmHg
[ Molecular Formula ]:
C17H21BrClNO
[ Molecular Weight ]:
370.71200
[ Flash Point ]:
194.1ºC
[ Exact Mass ]:
369.05000
[ PSA ]:
12.47000
[ LogP ]:
4.91870
[ Vapour Pressure ]:
1.61E-06mmHg at 25°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KQ8420000
- CHEMICAL NAME :
- Ethylamine, 2-((p-bromo-alpha-phenylbenzyl)oxy)-N,N-dimethyl-, hydrochloride
- CAS REGISTRY NUMBER :
- 1808-12-4
- LAST UPDATED :
- 199504
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C17-H20-Br-N-O.Cl-H
- MOLECULAR WEIGHT :
- 370.75
- WISWESSER LINE NOTATION :
- ER DYR&O2N1&1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 602 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 55 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 366 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 105 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 112,318,1954
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 63 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 21 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81737 No. of Facilities: 805 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 805 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81737 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 82 (estimated) No. of Female Employees: 14 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Precautionary Statements ]:
P301 + P312 + P330
[ RIDADR ]:
NONH for all modes of transport
[ HS Code ]:
2922199090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2922199090
[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%