Valdecoxib

Suppliers

Names

[ Name ]:
Valdecoxib

[Synonym ]:
4-(5-methyl-3-phenylisoxazol-4-yl)benzensulfonamide
Bextra(Valdecoxib)
4-(4-sulfamoylphenyl)-5-methyl-3-phenyl-isoxazole
T5NOJ C1 DR DSZW& ER
4-(5-Methyl-3-phenylisoxazol-4-yl)benzolsulfonamid
Bextra
Valdecoxib
4-[5-methyl-3-phenylisoxazol-4-yl ] benzenesulfonamide
[14C]-Valdecoxib
EINECS 448-010-8
Kudeq
Valdyn
4-(5-Methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide
4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide
p-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide
4-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonamide
MFCD00950568
Valdecoxib(R)
Benzenesulfonamide, 4-(5-methyl-3-phenyl-4-isoxazolyl)-

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
481.2±55.0 °C at 760 mmHg

[ Melting Point ]:
162-164ºC

[ Molecular Formula ]:
C₁₆H₁₄N₂O₃S

[ Molecular Weight ]:
314.359

[ Flash Point ]:
244.8±31.5 °C

[ Exact Mass ]:
314.072510

[ PSA ]:
94.57000

[ LogP ]:
1.71

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.609

[ Storage condition ]:
Store at RT

Safety Information

[ Symbol ]:

GHS08, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H361d-H373-H410

[ Precautionary Statements ]:
P273-P281-P501

[ Hazard Codes ]:
Xn,N

[ Risk Phrases ]:
63-48/22-51/53

[ Safety Phrases ]:
36/37-61

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4,5-Dihydro-5-methyl-3,4-diphenyl-5-isoxazolol
4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonyl chloride
1,2-Diphenylethanone oxime
Ethanoic anhydride
5-Methyl-3,4-diphenylisoxazole
4-iodo-5-methyl-3-phenyl-1,2-oxazole
4-SULFAMOYLPHENYLBORONIC ACID, PINACOL ESTER
4-Bromobenzenesulfonamide
(5-methyl-3-phenyl-1,2-oxazol-4-yl)boronic acid
5-methyl-3-phenyl-4-(4,4,5,5-tetramethyl[1.3.2]dioxaborolan-2-yl)-isoxazole

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

NFAT2 regulates COX-2 expression and modulates the integrin repertoire in endothelial cells at the crossroads of angiogenesis and inflammation.

Exp. Cell Res. 324(2) , 124-36, (2014)

The mechanisms controlling the switch between the pro-angiogenic and pro-inflammatory states of endothelial cells are still poorly understood. In this paper, we show that: (a) COX-2 expression induced...

Celecoxib increases lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1.

Oncotarget 6 , 39342-56, (2015)

The antitumorigenic mechanism of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib is still a matter of debate. Using lung cancer cell lines (A549, H460) and metastatic cells derived from a l...

Selective determination of COXIBs in environmental water samples by mixed-mode solid phase extraction and liquid chromatography quadrupole time-of-flight mass spectrometry.

J. Chromatogr. A. 1420 , 35-45, (2015)

The development and performance evaluation of a method for the simultaneous determination of six pharmaceuticals belonging to the class of non-steroidal anti-inflammatory drugs (NSAIDs) which present ...