3-[(1-Pyrrolidinylcarbonyl)methyl]coumarin

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Names

[ CAS No. ]:
18186-67-9

[ Name ]:
3-[(1-Pyrrolidinylcarbonyl)methyl]coumarin

Chemical & Physical Properties

[ Density]:
1.272g/cm3

[ Boiling Point ]:
479.2ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₅NO₃

[ Molecular Weight ]:
257.28400

[ Flash Point ]:
243.6ºC

[ Exact Mass ]:
257.10500

[ PSA ]:
50.52000

[ LogP ]:
1.89580

[ Vapour Pressure ]:
2.42E-09mmHg at 25°C

[ Index of Refraction ]:
1.598

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN8268000

CHEMICAL NAME :: Coumarin, 3-((1-pyrrolidinylcarbonyl)methyl)-

CAS REGISTRY NUMBER :: 18186-67-9

LAST UPDATED :: 198408

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H15-N-O3

MOLECULAR WEIGHT :: 257.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay)

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 88,755,1968

Related Compounds

3-(1-Pyrrolidinylcarbonyl)coumarin
3-(1-Methyl-1-phenylethyl)thiophene
3-(1-Methyl-1H-pyrazol-4-yl)-4,5-dihydro-1,2-oxazole-5-carboxylic acid
3-(1-methyl-2,3-dihydroindol-5-yl)prop-2-enoic acid
3-(1-methyl-3,4,5,6-tetrahydro-2H-pyridin-1-yl)propyl 2-(5-methyl-2-pr opan-2-yl-phenoxy)acetate iodide
2-Methyl-N-[3-(1-pyrrolidinylcarbonyl)phenyl]benzamide