6-chloro-3-ethyl-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide

Names

[ CAS No. ]:
1824-58-4

[ Name ]:
6-chloro-3-ethyl-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide

[Synonym ]:
Neo-diuresal
Ethiazidum [INN-Latin]
Etiazide [DCIT]
Aethiazidum
ETHIAZIDE
6-Chlor-7-sulfamoyl-3-aethyl-1,1-dioxy-3,4-dihydro-2H-1,2,4-benzothiadiazin
6-Chlor-3-aethyl-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazin-1,1-dioxid
Etiazida [INN-Spanish]
6-Chlor-3-aethyl-1,1-dioxy-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazin
Salta
Eclotizidum
6-Chlor-7-sulfamoyl-3-aethyl-3,4-dihydro-1,2,4-benzothiadiazin-1,1-dioxid
3-Ethylhydrochlorothiazide
Ethiazide [INN:BAN:JAN]

Chemical & Physical Properties

[ Density]:
1.526g/cm3

[ Boiling Point ]:
563.5ºC at 760mmHg

[ Molecular Formula ]:
C9H12ClN3O4S2

[ Molecular Weight ]:
325.79200

[ Flash Point ]:
294.6ºC

[ Exact Mass ]:
324.99600

[ PSA ]:
135.12000

[ LogP ]:
3.75600

[ Vapour Pressure ]:
1.01E-12mmHg at 25°C

[ Index of Refraction ]:
1.589

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DK9460000
CHEMICAL NAME :
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-ethyl-3,4-dihydro-, 1,1-dioxide
CAS REGISTRY NUMBER :
1824-58-4
LAST UPDATED :
199109
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C9-H12-Cl-N3-O4-S2
MOLECULAR WEIGHT :
325.81

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,110,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,110,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>310 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979

Safety Information

[ HS Code ]:
2935009090

Precursor & DownStream

Precursor

DownStream

  • 4-Amino-6-chlorobenzene-1,3-disulfonamide
  • 6-chloro-3-ethyl-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Related Compounds

  • benzyl N-(3-bromo-1H-pyrazol-4-yl)carbamate
  • benzyl N-[1-(6-chloropyridin-3-yl)cyclobutyl]carbamate
  • benzyl N-[2-(3-hydroxyoxan-3-yl)ethyl]carbamate
  • tert-butyl N-[2-(chloromethyl)-5,6-dimethylfuro[2,3-d]pyrimidin-4-yl]carbamate
  • benzyl N-(2-bromo-4-methoxyphenyl)carbamate
  • 5-(1-acetylpyrrolidin-2-yl)-1H-1,2,3-triazole-4-carboxylic acid
  • 3-Acetamido-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxylic acid
  • 2-Acetyl-3,3-dimethyl-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid
  • 3-[N-(1H-1,2,3,4-tetrazol-5-yl)acetamido]benzoic acid
  • 4-(2,2,2-Trifluoroacetamido)quinoline-2-carboxylic acid
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