1,3,4,5-Tetrahydro-7-chloro-5-phenyl-2H-1,4-benzodiazepin-2-one

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Names

[ CAS No. ]:
1824-69-7

[ Name ]:
1,3,4,5-Tetrahydro-7-chloro-5-phenyl-2H-1,4-benzodiazepin-2-one

[Synonym ]:
7-Chlor-2-oxo-5-phenyl-1.2.3.4-tetrahydro-5H-1.4-benzodiazepin
5-phenyl-7-chloro-1,3,4,5-tetrahydro-2H-1,4-benzodiazepine-2-one
7-chloro-5-phenyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one
2H-1,4-BENZODIAZEPIN-2-ONE,7-CHLORO-5-PHENYL-1,3,4,5-TETRAHYDRO
7-Chlor-1,3,4,5-tetrahydro-5-phenyl-2H-1,4-benzodiazepin-2-on
7-Chlor-1,2,4,5-tetrahydro-5-phenyl-3H-1,4-benzodiazepin-2-on
Ro 5-2181
7-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-2-one
7-Chloro-1,3,4,5-tetrahydro-5-phenyl-2H-1,4-benzodiazepin-2-one
2H-1,4-Benzodiazepin-2-one,1,3,4,5-tetrahydro-7-chloro-5-phenyl
1,3,4,5-Tetrahydro-7-chloro-5-phenyl-2H-1,4-benzodiazepin-2-one

Chemical & Physical Properties

[ Density]:
1.247g/cm3

[ Boiling Point ]:
440.8ºC at 760 mmHg

[ Molecular Formula ]:
C15H13ClN2O

[ Molecular Weight ]:
272.73000

[ Flash Point ]:
220.4ºC

[ Exact Mass ]:
272.07200

[ PSA ]:
41.13000

[ LogP ]:
3.43790

[ Vapour Pressure ]:
5.73E-08mmHg at 25°C

[ Index of Refraction ]:
1.597

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DF2275000
CHEMICAL NAME :
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-phenyl-1,3,4,5-tetrahydro-
CAS REGISTRY NUMBER :
1824-69-7
BEILSTEIN REFERENCE NO. :
0753609
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C15-H13-Cl-N2-O
MOLECULAR WEIGHT :
272.75
WISWESSER LINE NOTATION :
T67 GMV JM&TJ CG KR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 154,131,1965
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
335 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,168,1972

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%


Related Compounds

  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • tert-butyl N-methyl-N-[2-(3-methyl-1,2-thiazol-5-yl)-2-oxoethyl]carbamate
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • 5-chloro-6-(3-oxo-2,3-dihydro-1H-pyrazol-1-yl)pyridine-3-carboxylic acid
  • 3-(2,2,3,3,4,4,4-Heptafluorobutyl)azetidine
  • 2-acetamido-3-{5H-pyrrolo[2,3-b]pyrazin-7-yl}propanoic acid
  • 4,5-Dibromo-2-iodophenol