fluorophenothiazine dihydrochloride
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Names
Chemical & Physical Properties
[ Density]:
1.256g/cm3
[ Boiling Point ]:
600.4ºC at 760 mmHg
[ Molecular Formula ]:
C24H31ClF3N3O2S
[ Molecular Weight ]:
518.03500
[ Flash Point ]:
316.9ºC
[ Exact Mass ]:
517.17800
[ PSA ]:
64.48000
[ LogP ]:
5.06750
[ Vapour Pressure ]:
2.9E-15mmHg at 25°C
[ Index of Refraction ]:
1.567
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KM5425000
- CHEMICAL NAME :
- Ethanol, 2-(2-(4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)pro pyl)-1-piperazinyl)et hoxy)-, dihydrochloride
- CAS REGISTRY NUMBER :
- 1827-91-4
- LAST UPDATED :
- 199506
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C24-H30-F3-N3-O2-S.2Cl-H
- MOLECULAR WEIGHT :
- 554.55
- WISWESSER LINE NOTATION :
- T C666 BN ISJ EXFFF B3- AT6N DNTJ D2O2Q &GH 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 588 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - chromodacryorrhea Sense Organs and Special Senses (Eye) - ptosis Behavioral - rigidity (including catalepsy)
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 136,476,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 199 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - chromodacryorrhea Sense Organs and Special Senses (Eye) - ptosis Behavioral - rigidity (including catalepsy)
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 136,476,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 136,476,1962