AM404

Suppliers

Names

[ Name ]:
AM404

[Synonym ]:
N-(4-Hydroxyphenyl)-arachidonylamide
5,8,11,14-Eicosatetraenamide, N-(4-hydroxyphenyl)-, (5Z,8Z,11Z,14Z)-
AM 404
(5Z,8Z,11Z,14Z)-N-(4-Hydroxyphenyl)icosa-5,8,11,14-tetraenamide
N-(4-Hydroxyphenyl)arachidonylamide
AM-404
AM404
(5Z,8Z,11Z,14Z)-N-(4-Hydroxyphenyl)-5,8,11,14-icosatetraenamide

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
579.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₃₇NO₂

[ Molecular Weight ]:
395.578

[ Flash Point ]:
304.2±30.1 °C

[ Exact Mass ]:
395.282440

[ PSA ]:
49.33000

[ LogP ]:
7.63

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.555

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H319

[ Precautionary Statements ]:
P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F: Flammable;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S7

[ RIDADR ]:
UN 1170 3/PG 2

Articles

Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia.

Transl. Psychiatry 2 , e94, (2012)

Cannabidiol is a component of marijuana that does not activate cannabinoid receptors, but moderately inhibits the degradation of the endocannabinoid anandamide. We previously reported that an elevatio...

The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats.

Br. J. Pharmacol. 165(8) , 2539-48, (2012)

The fatty acid amide hydrolase inhibitor URB597 can reverse the abuse-related behavioural and neurochemical effects of nicotine in rats. Fatty acid amide hydrolase inhibitors block the degradation (an...

Elevated circulating levels of anandamide after administration of the transport inhibitor, AM404.

Eur. J. Pharmacol. 408(2) , 161-8, (2000)

The biological actions of the endogenous cannabinoid anandamide are terminated by carrier-mediated transport into neurons and astrocytes, followed by enzymatic hydrolysis. Anandamide transport is inhi...

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