Gefitinib

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Names

[ CAS No. ]:
184475-35-2

[ Name ]:
Gefitinib

[Synonym ]:
Iressa
N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamide
MFCD04307832
Irressat
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine
N-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
N-(3-Chlor-4-fluorphenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]chinazolin-4-amin
N-(3-Chlor-4-fluorphenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)chinazolin-4-amin
N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine
N-(3-chloro-4-fluorophényl)-7-méthoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
ZD-1839
Gefitinib
4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
ZD1839

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
586.8±50.0 °C at 760 mmHg

[ Melting Point ]:
119-1200C

[ Molecular Formula ]:
C22H24ClFN4O3

[ Molecular Weight ]:
446.902

[ Flash Point ]:
308.7±30.1 °C

[ Exact Mass ]:
446.152100

[ PSA ]:
68.74000

[ LogP ]:
4.11

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.621

[ Storage condition ]:
Store at RT

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P301 + P312 + P330-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
HP1149700

[ HS Code ]:
29143900

Precursor & DownStream

Precursor

  • Gefitinib impurity 5
  • 3-Chloro-4-fluoroaniline
  • 4-(3-Chloropropyl)morpholine
  • FAAH-IN-2
  • morpholine
  • 6-(3-chloropropoxy)-N- (3-chloro-4-fluorophenyl)-7-Methoxyquinazolin-4-aMine
  • Methyl isovanillate

DownStream

  • O-Desmethyl gefitinib
  • Gefitinib impurity 5

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • Gefitinib
  • Gefitinib D8
  • Gefitinib-d6
  • Gefitinib-d3
  • Gefitinib N-oxide
  • Gefitinib impurity 5
  • 3-hydroxy-3-[3-(trifluoromethyl)-1H-pyrazol-4-yl]propanenitrile
  • 4-Acetyl-3-methyl-2-(trifluoromethyl)benzonitrile
  • (I+/-R)-I+/--Amino-3-chloro-N-(1,1-dimethylethyl)benzeneacetamide
  • Methyl 3-bromo-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate
  • 1-(3-Iodo-4-(trifluoromethyl)phenyl)propan-2-one
  • 1-Bromo-1-(2,5-diethylphenyl)propan-2-one
  • 3-Pyridinecarboxaldehyde, 2-(dimethylamino)-5-(methylthio)-
  • 2-(4-Bromo-2-fluoro-6-iodophenyl)acetic acid
  • (3S)-3-amino-3-methyl-5-(trifluoromethyl)-1H-indol-2-one
  • 7-Chloro-3-isopropyl-5-methylpyrazolo[1,5-a]pyrimidine
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