4-Methylcinnamic acid

Suppliers

Names

[ Name ]:
4-Methylcinnamic acid

[Synonym ]:
4-Methylciamic acid
BASF Luwipal 044
3-(4-methylphenyl)-2-propenoic acid
3-(p-Tolyl)acrylic acid
3-(4-Methylphenyl)acrylic acid
trans-4-methylcinnamic acid
3-P-TOLYL-ACRYLIC ACID
(2E)-3-(4-Methylphenyl)acrylic acid
(2E)-3-(4-methylphenyl)prop-2-enoic acid
4-MethylcinnaMic Acid
P-methycinnamic acid
2-Propenoic acid, 3-(4-methylphenyl)-, (2E)-
p-Methyl cinnamic acid
P-METHYLCINNAMIC ACID
2-Propenoic acid, 3-(4-methylphenyl)-
MFCD00002697
RARECHEM BK HC T309
EINECS 217-479-9

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
300.6±11.0 °C at 760 mmHg

[ Melting Point ]:
196-198 °C(lit.)

[ Molecular Formula ]:
C₁₀H₁₀O₂

[ Molecular Weight ]:
162.185

[ Flash Point ]:
206.1±10.2 °C

[ Exact Mass ]:
162.068085

[ PSA ]:
37.30000

[ LogP ]:
2.87

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.603

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-Bromotoluene
Acrylic acid
4-Iodotoluene
4-methylbenzenediazonium tetrafluoroborate
carbon monoxide
(E)-β-bromo-p-methylstyrene
Malonic acid
p-Tolualdehyde
acrylic acid methyl ester
Sodium acrylate

DownStream

1-Methyl-4-((E)-styryl)-benzene
3-Amino-3-p-tolyl-propionic acid
4-Methylphenyl-L-alanine
4-Methylstyrene
3-Chloro-6-methylbenzothiophene-2-carbonyl chloride
methyl 3-(4-methylphenyl)butanoate
2,4-Diaminotoluene
p-Tolualdehyde
Glyoxylic acid
Methyl 4-methylcinnamate

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins

Bioorg. Med. Chem. 17 , 896-904, (2009)

This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...

Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A).

Bioorg. Med. Chem. Lett. 21 , 2736-9, (2011)

Nicotinic acid (niacin) has been used for decades as an antidyslipidemic drug in man. Its main target is the hydroxy-carboxylic acid receptor HCA2 (GPR109A), a G protein-coupled receptor. Other acids ...