Roscovitine (CYC202)

Suppliers

Names

[ Name ]:
Roscovitine (CYC202)

[Synonym ]:
CYC 202
(2R)-2-{[6-(Benzylamino)-9-isopropyl-9H-purin-2-yl]amino}butan-1-ol
P34 CDC2
6-Benzylamino-2[(R)-(1'-ethyl-2'-hydroxyethylamino)]-9-isopropylpurine Roscovitine
R-roscovitine
(+)-Seliciclib
MFCD02266401
(R)-Roscovitine
(R)-2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol
(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol
Seliciclib
1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)-
Roscovitine
Roscovitin
(2R)-2-{[6-(Benzylamino)-9-isopropyl-9H-purin-2-yl]amino}-1-butanol
CYC202
CYC202 Cyclacel

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
577.5±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₆N₆O

[ Molecular Weight ]:
354.449

[ Flash Point ]:
303.1±32.9 °C

[ Exact Mass ]:
354.216797

[ PSA ]:
87.89000

[ LogP ]:
1.68

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.643

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

CDK5 is a major regulator of the tumor suppressor DLC1.

J. Cell Biol. 207(5) , 627-42, (2014)

DLC1 is a tumor suppressor protein whose full activity depends on its presence at focal adhesions, its Rho-GTPase activating protein (Rho-GAP) function, and its ability to bind several ligands, includ...

Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress.

Oncotarget 6 , 13072-87, (2015)

The therapeutic efficacy of nucleoside analogues, e.g. gemcitabine, against cancer cells can be augmented by inhibitors of checkpoint kinases, including Wee1, ATR, and Chk1. We have compared the chemo...

PKA and CDK5 can phosphorylate specific serines on the intracellular domain of podoplanin (PDPN) to inhibit cell motility.

Exp. Cell Res. 335 , 115-22, (2015)

Podoplanin (PDPN) is a transmembrane glycoprotein that promotes tumor cell migration, invasion, and cancer metastasis. In fact, PDPN expression is induced in many types of cancer. Thus, PDPN has emerg...