Diphenylacetyl chloride

Suppliers

Names

[ CAS No. ]:
1871-76-7

[ Name ]:
Diphenylacetyl chloride

[Synonym ]:
2,2-di(phenyl)acetyl chloride
2,2-di(phenyl)ethanoyl chloride
Diphenylacetyl chloride
Diphenylacetic acid chloride
EINECS 217-493-5
2,2-diphenylacetyl chloride
α,α-Diphenylacetyl chloride
Acetyl chloride,diphenyl
1,1-diphenylacetyl chloride
MFCD00013655
Benzeneacetyl chloride, α-phenyl-
2,2-diphenylethanoyl chloride

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
304.9±0.0 °C at 760 mmHg

[ Melting Point ]:
49-53 °C(lit.)

[ Molecular Formula ]:
C14H11ClO

[ Molecular Weight ]:
230.689

[ Flash Point ]:
154.9±18.0 °C

[ Exact Mass ]:
230.049850

[ PSA ]:
17.07000

[ LogP ]:
3.96

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.584

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AO6750000
CHEMICAL NAME :
Acetyl chloride, diphenyl-
CAS REGISTRY NUMBER :
1871-76-7
BEILSTEIN REFERENCE NO. :
1211588
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C14-H11-Cl-O
MOLECULAR WEIGHT :
230.70
WISWESSER LINE NOTATION :
GVYR&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6330 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - ataxia
REFERENCE :
GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 17,48,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4700 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - ataxia
REFERENCE :
GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 17,48,1978 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
37980 mg/kg/26W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in erythrocyte (RBC) count Related to Chronic Data - death
REFERENCE :
GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 17,48,1978

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R34;R36/37

[ Safety Phrases ]:
S26-S27-S28-S36/37/39-S45

[ RIDADR ]:
UN 3261 8/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
AO6750000

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
29163900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2,2-Diphenylacetic acid
  • Oxalyl chloride
  • Benzeneacetamide, a-phenyl-
  • DIPHENYLKETENE
  • Benzilic acid
  • 2-chloro-2,2-diphenylacetyl chloride
  • 2-anilino-2-oxoacetyl chloride
  • SUCCINYL CHLORIDE
  • Acetyl chloride

DownStream

  • 2-(Diphenylacetylamino)-3-ethoxycarbonyl<2,3-b>quinuclidine
  • 2-(4-methylpiperazin-1-yl)ethyl 2,2-diphenylacetate,dihydrochloride
  • methyl diphenylacetate
  • Ethanone,1-(4-morpholinyl)-2,2-diphenyl-
  • 2,2-Diphenylethanamine
  • Acetamide,N-(cyanomethyl)-2,2-diphenyl- (8CI)
  • diethyl 2-(2,2-diphenylacetyl)propanedioate
  • 1-Butanamine,N-(2,2-diphenylethenylidene)-
  • 2-Azetidinone,1,3,3,4-tetraphenyl-
  • 1,1-Diphenylethane

Customs

[ HS Code ]: 29163900

Articles

Selective pivaloylation and diphenylacetylation of cyclomalto-oligosaccharides.

Carbohydr. Res. 262(2) , 271-82, (1994)

Regioselective acylation of cyclomalto-oligosaccharides was achieved using pivaloyl and diphenylacetyl chlorides. The reaction of cyclomaltohexaose (1) with pivaloyl chloride gave the hexakis(2,6-di-O...

Synthesis and pharmacological screening of certain N-substituted amides structurally related to some local anesthetics.

Pharmazie 34(1) , 12-3, (1979)

Diphenylacetyl chloride and pivaloyl chloride have been condensed with a wide variety of amines. Some of the resulting amides showed local anesthetic properties higher than those of procaine hydrochlo...


More Articles

Related Compounds

  • Chlorodiphenylacetyl chloride
  • 2-bromo-2,2-diphenylacetyl chloride
  • 2-hydroxy-2,2-diphenylacetyl chloride
  • (Diphenylacetyl)(2,4-dioxo-5,5-diphenyl-3-oxazolidinyl)carbamidsaeure-tert-butylester
  • 2-(2,2-diphenylacetyl)oxybutyl-diethylazanium,chloride
  • 2-(2,2-diphenylacetyl)oxypentyl-diethylazanium,chloride