(4-amino-7-fluorocinnolin-3-yl)-(4-pyridin-2-ylpiperazin-1-yl)methanone

Names

[ CAS No. ]:
187231-58-9

[ Name ]:
(4-amino-7-fluorocinnolin-3-yl)-(4-pyridin-2-ylpiperazin-1-yl)methanone

Chemical & Physical Properties

[ Density]:
1.409g/cm3

[ Boiling Point ]:
638.7ºC at 760 mmHg

[ Molecular Formula ]:
C18H17FN6O

[ Molecular Weight ]:
352.36600

[ Flash Point ]:
340.1ºC

[ Exact Mass ]:
352.14500

[ PSA ]:
88.24000

[ LogP ]:
2.29260

[ Vapour Pressure ]:
3.26E-16mmHg at 25°C

[ Index of Refraction ]:
1.694

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TK8050833
CHEMICAL NAME :
Piperazine, 1-((4-amino-7-fluoro-3-cinnolinyl)carbonyl)-4-(2-pyri dinyl)-
CAS REGISTRY NUMBER :
187231-58-9
LAST UPDATED :
199803
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C18-H17-F-N6-O
MOLECULAR WEIGHT :
352.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 52,91,1997
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 52,91,1997

Related Compounds

  • 2-Methanesulfonylpropan-1-amine hydrochloride
  • 2-Bromonaphtho[2,1-d]thiazole
  • Ethyl 5-oxohex-2-enoate
  • (R)-(8-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol
  • 1-(5-Chloro-6-methoxypyridin-2-yl)ethanone
  • 5-Chloro-6-methoxypicolinamide
  • (3-(tert-Butyl)pyridin-2-yl)methanamine
  • 6-Bromo-7-chloro-2-methyl-3H-imidazo[4,5-b]pyridine
  • 6-Bromo-7-chloro-2-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine
  • 1-(2-(Difluoromethoxy)pyridin-4-yl)ethanone
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