Tetrahydrouridine

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Names

[ CAS No. ]:
18771-50-1

[ Name ]:
Tetrahydrouridine

[Synonym ]:
4-Hydroxy-1-(β-D-ribofuranosyl)tetrahydro-2(1H)-pyrimidinone
Tetrahydro-uridin
2(1H)-Pyrimidinone, tetrahydro-4-hydroxy-1-β-D-ribofuranosyl-
UNII:0NIZ8H6OL8
3,4,5,6-tetrahydrouridine

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
668.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C9H16N2O6

[ Molecular Weight ]:
248.233

[ Flash Point ]:
358.2±31.5 °C

[ Exact Mass ]:
248.100830

[ PSA ]:
130.33000

[ LogP ]:
-1.85

[ Vapour Pressure ]:
0.0±4.6 mmHg at 25°C

[ Index of Refraction ]:
1.632

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UW5798980
CHEMICAL NAME :
2(1H)-Pyrimidinone, tetrahydro-4-hydroxy-1-beta-D-ribofuranosyl-
CAS REGISTRY NUMBER :
18771-50-1
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C9-H16-N2-O6
MOLECULAR WEIGHT :
248.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB211-590
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 10,423,1976
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 10,423,1976

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 56-Dihydrouridine

DownStream

Related Compounds

  • 2'-deoxytetrahydrouridine
  • (7-Methyl-4-((3-(trifluoromethyl)phenyl)amino)-1,8-naphthyridin-3-yl)(thiomorpholino)methanone
  • N-[4-(2,5-dimethylphenyl)-1,3-thiazol-2-yl]-5-fluoropyridin-2-amine
  • 5-fluoro-N-[4-(2,4,5-trimethylphenyl)-1,3-thiazol-2-yl]pyridin-2-amine
  • methyl 4-((2-(1,3,4-oxadiazol-2-yl)-1H-indol-1-yl)methyl)benzoate
  • Ethyl 1-(3-fluorophenyl)pyrazole-3-carboxylate
  • N-(4-methylcyclohexyl)-3-(1H-pyrrol-1-yl)thieno[2,3-b]pyridine-2-carboxamide
  • Methyl 3-(4-ethoxyphenyl)-4-oxo-2-(piperidin-1-yl)-3,4-dihydroquinazoline-7-carboxylate
  • 3-(3-(benzo[d][1,3]dioxol-5-yl)-1,2,4-oxadiazol-5-yl)-1-(3,4-difluorophenyl)pyridazin-4(1H)-one
  • 2-phenyl-N-(pyridin-2-ylmethyl)-2-(1H-pyrrol-1-yl)acetamide
  • N-(5-fluoro-2-methylphenyl)-2-(4-oxo-3,4,5,6,7,8-hexahydroquinazolin-3-yl)acetamide
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