rac-6-Chloro Voriconazole

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Names

[ CAS No. ]:
188416-35-5

[ Name ]:
rac-6-Chloro Voriconazole

[Synonym ]:
4-Pyrimidineethanol, 6-chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αS,βR)-, hydrochloride (1:1)
Vfend
MFCD07772028
(2R,3S)-2-(2,4-Difluorphenyl)-3-(5-fluorpyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
(R-(R*,S*))-a-(2,4-difluorophenyl)-5-fluoro-b-methyl-a-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
4-Pyrimidineethanol, 6-chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-
(2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol
(2S,3R)-3-(6-Chloro-5-fluoro-4-pyrimidinyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol hydrochloride (1:1)
3-(6-Chlor-5-fluorpyrimidin-4-yl)-2-(2,4-difluorphenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)butan-2-ol,hydrochloride
(2S,3R)-3-(6-Chloro-5-fluoro-4-pyrimidinyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol hydrochloride
4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βS)-
(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
Voriconazole
(2R,3S)-2-(2,4-difluorophényl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
Vorionazole
3-(6-Chloro-5-fluoro-4-pyrimidinyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol
(aR,bS)-a-(2,4-difluorophenyl)-5-fluoro-b-methyl-a-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
3-(6-Chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)butan-2-ol
(2R.3S/2S.3R) -3-(4-CHLORO-5-FLUOROPYRIMIDIN-6-YL)-2 -(2,4-D IFLUOROPHENYL)-1-(1H-1,2,4-TRIAZOL-1-YL) BUTAN-2-OL HYDROCHL
Voriconazole Impurity 9

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
529.9±60.0 °C at 760 mmHg

[ Melting Point ]:
183-187°C

[ Molecular Formula ]:
C16H14Cl2F3N5O

[ Molecular Weight ]:
420.216

[ Flash Point ]:
274.2±32.9 °C

[ Exact Mass ]:
419.052765

[ PSA ]:
76.72000

[ LogP ]:
1.84

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.629

[ Storage condition ]:
Refrigerator

Safety Information

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone
  • 4-Chloro-2-methylsulfanyl-pyrimidine-5-carbonitrile
  • 6-Ethyl-5-fluoropyrimidin-4(3H)-one

DownStream

  • Voriconazole
  • (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • rac-6-Chloro Voriconazole
  • rac 6-Chloro-1,4-dihydro-4-(1-pentynyl)-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
  • rac-6-chloro-1,5-dihydro-3-methyl-imidazo[2,1-b]quinazolin-2-(3H)-one
  • 6-chloro-2-methanesulfinyl-benzothiazole
  • rac Efavirenz
  • rac Methyl Efavirenz
  • (4R)-3-(2-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethyl]sulfanyl}acetyl)-1,3-thiazolidine-4-carboxylic acid
  • 1-(1-methyl-1H-1,2,3-triazol-5-yl)ethane-1,2-diol
  • 4-chloro-2-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanamido]benzoic acid
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Fluoro-3-methyl-4,4'-bipyridine
  • rac-3-{2-[(1R,2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopentyl]-N-methylacetamido}-2-methylpropanoic acid
  • 3-[(2,5-Dimethylthiophen-3-yl)oxy]pyrrolidine
  • tert-butyl N-[3-oxo-3-(1,3-thiazol-5-yl)propyl]carbamate
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile