Phenethylamine, .α.-methyl-m-trifluoromethyl

Names

[ Name ]:
Phenethylamine, .α.-methyl-m-trifluoromethyl

[Synonym ]:
1-(3-trifluoromethylphenyl)-2-amino propane
3(3-trifluoromethylphenyl)-2-aminopropane
[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amine
norfenfluramine
(+/-)-[1-(3-trifluoromethyl)phenyl]-2-propylamine

Chemical & Physical Properties

[ Density]:
1.152g/cm3

[ Boiling Point ]:
215.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₁₂F₃N

[ Molecular Weight ]:
203.20400

[ Flash Point ]:
88.9ºC

[ Exact Mass ]:
203.09200

[ PSA ]:
26.02000

[ LogP ]:
3.29540

[ Vapour Pressure ]:
0.15mmHg at 25°C

[ Index of Refraction ]:
1.466

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SI1800000

CHEMICAL NAME :: Phenethylamine, alpha-methyl-m-trifluoromethyl-

CAS REGISTRY NUMBER :: 1886-26-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H12-F3-N

MOLECULAR WEIGHT :: 203.23

WISWESSER LINE NOTATION :: Z1Y1&R CXFFF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 51 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 17XKAB "International Symposium on Amphetamines and Related Compounds, Proceedings, Mario Negri Institute for Pharmacological Research, Milan, 1969," Costa, E., and S. Garattini, eds., New York, Raven Press, 1970 Volume(issue)/page/year: -,21,1970

Safety Information

[ HS Code ]:
2921499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1-(3-(TRIFLUOROMETHYL)PHENYL)-2-NITROPROPENE
3-(Trifluoromethyl)benzaldehyde

DownStream

levofenfluramine
3-[[1-Methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amino]-1-propanol
4-oxo-4-[2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethoxy]butanoic acid
2-[[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amino]ethanol
Benfluorex
2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl 4-aminobenzoate
2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl 2-chlorobenzoate
2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl 2-(4-chlorophenyl)acetate
2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl cyclopropanecarboxylate
2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl 4-fluorobenzoate

Customs

[ HS Code ]: 2921499090

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Related Compounds

Phenethylamine, alpha-ethyl-alpha-methyl-m-trifluoromethyl-
3-[[α-Methyl-m-(trifluoromethyl)phenethyl]carbamoyl]propenoic acid
N-[α-Methyl-m-(trifluoromethyl)phenethyl]-3-piperidinopropionamide
N-[α-Methyl-m-(trifluoromethyl)phenethyl]benzamide
N-[α-Methyl-m-(trifluoromethyl)phenethyl]-2-phenylacetamide
N-[α-Methyl-m-(trifluoromethyl)phenethyl]-3-phenylpropenamide
(S)-1-Acryloyl-N-(1-(5-chlorothiophen-2-yl)ethyl)piperidine-4-carboxamide
CID 145888748
Tert-butyl 2-(1-{4-[(prop-2-enamido)methyl]benzoyl}azepan-4-yl)acetate
N-(4-Cyano-1-methylpiperidin-4-yl)-2-(3-oxo-1H-isoindol-2-yl)acetamide
2-Ethynylbenzene-1-carboximidamide
N-(1,4-Dioxaspiro[4.4]nonan-3-ylmethyl)-3-(prop-2-enoylamino)propanamide
N-((1,4-Dioxaspiro[4.4]nonan-2-yl)methyl)-1-acryloylpiperidine-4-carboxamide
N-[4-(3,3-Dimethylmorpholine-4-carbonyl)phenyl]prop-2-enamide
N-(1-Tert-butyl-3,5-dimethylpyrazol-4-yl)-4-[(prop-2-enoylamino)methyl]benzamide
N-[3-(5-Methyl-6-nitro-2,3-dihydroindol-1-yl)-3-oxopropyl]prop-2-enamide

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