L-Glutamic acid,N-[4-[[(2,4-diamino-6-quinazolinyl)methyl]amino]benzoyl]-

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Names

[ CAS No. ]:
18921-68-1

[ Name ]:
L-Glutamic acid,N-[4-[[(2,4-diamino-6-quinazolinyl)methyl]amino]benzoyl]-

[Synonym ]:
Deazaminopterin
Deaza-Aminopterin
Dideaza-aminopterin
N-{4-[(2,4-diamino-quinazolin-6-ylmethyl)-amino]-benzoyl}-glutamic acid
N-[4-[[(2,4-Diaminoquinazolin-6-yl)methyl]amino]benzoyl]-L-glutamic acid
CB-3702
5,8-Dideazaaminopterin

Chemical & Physical Properties

[ Density]:
1.508g/cm3

[ Molecular Formula ]:
C21H22N6O5

[ Molecular Weight ]:
438.43700

[ Exact Mass ]:
438.16500

[ PSA ]:
193.55000

[ LogP ]:
3.08040

[ Index of Refraction ]:
1.747

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MA1247500
CHEMICAL NAME :
Glutamic acid, N-(p-(((2,4-diamino-6-quinazolinyl)methyl)amino)benzo yl)-, L-
CAS REGISTRY NUMBER :
18921-68-1
LAST UPDATED :
198312
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C21-H22-N6-O5
MOLECULAR WEIGHT :
438.49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
65 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2709506
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
65 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2709506

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 3-(2,5-dimethylphenylsulfonyl)-N-isopentylthieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine
  • N-cycloheptyl-3-((2,5-dimethylphenyl)sulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine
  • N-[2-[3,4-Bis(phenylmethoxy)phenyl]ethyl]-3,4,5-trimethoxybenzeneacetamide
  • Ethyl 1-(3-((2,5-dimethylphenyl)sulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-yl)piperidine-4-carboxylate
  • 3-((2,5-dimethylphenyl)sulfonyl)-N-(4-isopropylphenyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine
  • 3-(3,4-dimethoxyphenyl)-2,8-dimethyl-5,6-dihydro-2H-2,6-methanobenzo[g][1,3,5]oxadiazocin-4(3H)-one
  • 3-(2,8-dimethyl-4-oxo-5,6-dihydro-2H-2,6-methano-1,3,5-benzoxadiazocin-3(4H)-yl)benzoic acid
  • 6-Methoxy-1-methyl-3-(4-methylbenzenesulfonyl)-1,4-dihydroquinolin-4-one
  • 6-ethoxy-3-((4-fluorophenyl)sulfonyl)-1-methylquinolin-4(1H)-one
  • 1-ethyl-6-methoxy-3-tosylquinolin-4(1H)-one
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