Chloromethyl pivalate

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Names

[ CAS No. ]:
18997-19-8

[ Name ]:
Chloromethyl pivalate

[Synonym ]:
Methanol,chloro-,pivalate
chloromethyl trimethylacetate
Propanoic acid, 2,2-dimethyl-, chloromethyl ester
pivalic acid chloromethyl ester
POM-CL
Chloromethyl Pivalate [Amino-Protecting Agent]
Chloromethyl 2,2-dimethylpropanoate
CHLOROMETHYL PIVARATE
chloromethyl 2,2-dimethylpropionate
Pivaloxymethylchlorde
2,2-Dimethyl-propionic acid chloromethyl ester
POM
CMPV
PIVALOYLOXYMETHYL CHLORIDE
CHLORO METHYL PIVILATE
Chlormethyl-2,2-dimethylpropanoat
2,2-Dimethylpropionic Acid Chloromethyl Ester
MFCD00000884
Chloromethyl pivalate
Trimethylacetic Acid Chloromethyl Ester
EINECS 242-735-1
Adefovir Impurity 13

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
143.0±13.0 °C at 760 mmHg

[ Melting Point ]:
<-40ºC

[ Molecular Formula ]:
C6H11ClO2

[ Molecular Weight ]:
150.603

[ Flash Point ]:
40.0±0.0 °C

[ Exact Mass ]:
150.044754

[ PSA ]:
26.30000

[ LogP ]:
1.64

[ Vapour Pressure ]:
5.5±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.425

[ Storage condition ]:
Flammables area

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H302 + H312 + H332-H315-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R10;R36/37/38

[ Safety Phrases ]:
S16-S26-S36-S41-S36/37/39

[ RIDADR ]:
UN 3272 3/PG 3

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
2915600000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Formaldehyde
  • Pivaloyl chloride
  • Bromochloromethane
  • sodium pivalate
  • Potassium triMethylacetate
  • Chloromethyl chlorosulfate
  • Pivalic acid
  • Methyl pivalate

DownStream

  • Ticlopidine Hydrochloride
  • N1-(Pivaloyloxy)methyl-N2-(dimethylamino)methylene 9-Deazaguanine
  • Propanoic acid,2,2-dimethyl-, 4-nitrophenyl ester
  • 2,2-dimethylpropionic acid (4-nitrophenoxy)methyl ester
  • 7-Hydroxy-6-methoxy-3-[(pivaloyloxy)methyl]-3,4-dihydroquinazolin-4-one
  • (4-methoxyphenyl) 2,2-dimethylpropanoate
  • pivampicillin
  • Iodomethyl pivalate
  • Sulbactam pivoxil
  • Adefovir Dipivoxil

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Articles

Synthesis of an Isoindoline-Annulated, Tricyclic Sultam Library via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS).

Synthesis 44(16) , doi:10.1055/s-0031-1289791, (2012)

A microwave-assisted, continuous-flow organic synthesis (MACOS) protocol for the synthesis of an isoindoline-annulat-ed, tricyclic sultam library, utilizing a Heck-aza-Michael (HaM) strategy, is repor...

Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine.

Antiviral Res. 19(3) , 267-73, (1992)

9-(2-Phosphonylmethoxyethyl)adenine (PMEA; 1) was acylated with chloromethyl pivalate to afford bis(pivaloyloxymethyl) PMEA (2). The ester prodrug demonstrated enhanced in vitro potency against HSV-2 ...

An efficient method for the synthesis of sulbactam pivoxil.

Il Farmaco 55(2) , 134-5, (2000)

Sulbactam pivoxil, a prodrug of the beta-lactamase inhibitor sulbactam, was prepared in high yield by reacting the sodium salt of sulbactam with chloromethyl pivalate in a polar solvent, then diluting...


More Articles

Related Compounds

  • Chloromethyl Pivalate
  • chloromethyl pivalate
  • Chloromethyl 3-((tert-butoxycarbonyl)amino)propanoate
  • chloromethyl-[2-[ethynyl(dimethyl)silyl]ethynyl]-dimethylsilane
  • CHLOROMETHYL PHENYL SULFONE
  • (chloromethyl)(2-oxo-2-phenylethyl)mercury
  • 4-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3,3,3-trifluoropropanamido]-2-methoxybutanoic acid
  • N-(5-chloro-2-methylphenyl)-2-cyclopropyl-6-(difluoromethyl)pyrimidine-4-carboxamide
  • 2-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-methylhexanamido]methyl}-2-methylbutanoic acid
  • 2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-methylhexanoyl]-2-azabicyclo[2.1.1]hexane-5-carboxylic acid
  • (2S,3R)-3-(benzyloxy)-2-{2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-3-methylbutanamido}butanoic acid
  • tert-butyl N-[2-(cyclohex-1-en-1-yl)-2-oxoethyl]carbamate
  • (2R,3S)-3-(benzyloxy)-2-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-1,3-thiazol-4-yl]formamido}butanoic acid
  • (2R,3S)-3-(benzyloxy)-2-{[(1RS,2SR)-2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclopentyl]formamido}butanoic acid
  • 2-cyclopropyl-6-(difluoromethyl)-N-(3,5-dimethylphenyl)pyrimidine-4-carboxamide
  • (2R,3S)-3-(benzyloxy)-2-{[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)phenyl]formamido}butanoic acid
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