N-METHYLISATIN-3-THIOSEMICARBAZONE

Suppliers

Names

[ CAS No. ]:
1910-68-5

[ Name ]:
N-METHYLISATIN-3-THIOSEMICARBAZONE

[Synonym ]:
Metisazon
Viruzona
Metisazonum
N-methylisatin-3-thiosemicarbazone
methisazone
[(1-methyl-2-oxoindol-3-ylidene)amino]thiourea
[(Z)-(1-methyl-2-oxoindol-3-ylidene)amino]thiourea
Marboran
N-Methylisatin thiosemicarbazone
Kemoviran

Chemical & Physical Properties

[ Density]:
1.47 g/cm3

[ Boiling Point ]:
410.3ºC at 760 mmHg

[ Melting Point ]:
245°

[ Molecular Formula ]:
C10H10N4OS

[ Molecular Weight ]:
234.28

[ Flash Point ]:
202ºC

[ Exact Mass ]:
234.05800

[ PSA ]:
102.81000

[ LogP ]:
1.35650

[ Vapour Pressure ]:
6.07E-07mmHg at 25°C

[ Index of Refraction ]:
1.732

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NL7960000
CHEMICAL NAME :
Indole-2,3-dione, 1-methyl-, 3-(thiosemicarbazone)
CAS REGISTRY NUMBER :
1910-68-5
LAST UPDATED :
199106
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C10-H10-N4-O-S
MOLECULAR WEIGHT :
234.30
WISWESSER LINE NOTATION :
T56 BNVYJ B1 DUNMYZUS

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>50 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Human HeLa cell
DOSE/DURATION :
30 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 25,821,1976

Safety Information

[ HS Code ]:
2933790090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-methylisatin
  • Thiosemicarbazide
  • (2E)-2-(Hydroxyimino)-N-phenylacetamide
  • isatin

DownStream

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Related Compounds

  • N-methylisatin beta-4',4'-diethylthiosemicarbazone
  • 1-[[(1E)-1-(2,3-dihydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)ethyl]amino]-3-(3-methoxyphenyl)thiourea
  • N-[4-[(E)-(2-methylpropylthiocarbamoylhydrazinylidene)methyl]phenyl]acetamide
  • N-(3-methoxyphenyl)-4-(2-phenyl-1H-imidazol-5-yl)pyrimidin-2-amine
  • N-[3-cyano-4-(pyridin-2-ylmethyl)phenyl]butanamide
  • N-(3,5-dichloro-4-fluorophenyl)-2-methylpropanamide