4-Nitrothalidomide

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Names

[ CAS No. ]:
19171-18-7

[ Name ]:
4-Nitrothalidomide

[Synonym ]:
1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-nitro-isoindoline
2-(2,6-dioxo-piperidin-3-yl)-4-nitro-isoindole-1,3-dione
3-(1',3'-Dioxo-4'-nitroisoindolinyl-2')-2,6-dioxopiperidine
2-(2,6-dioxopiperidin-3-yl)-4-nitro-1H-isoindole-1,3(2H)-dione
4-Nitrothalidomide
2-(2,6-dioxopiperidine-3-yl)-4-nitrophthalimide
3-Nitrothalidomide
N-(2,6-Dioxo-3-piperidyl)-3-nitrophthalimide
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-nitro-
2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione
Phthalimide,N-(2,6-dioxo-3-piperidyl)-3-nitro
2-(2,6-Dioxo-3-piperidinyl)-4-nitro-1H-isoindole-1,3(2H)-dione
Pomalidomide Impurity 6

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
603.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H9N3O6

[ Molecular Weight ]:
303.227

[ Flash Point ]:
318.7±30.1 °C

[ Exact Mass ]:
303.049133

[ PSA ]:
132.86000

[ LogP ]:
0.27

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.674

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TI4930000
CHEMICAL NAME :
Phthalimide, N-(2,6-dioxo-3-piperidyl)-3-nitro-
CAS REGISTRY NUMBER :
19171-18-7
LAST UPDATED :
198910
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C13-H9-N2-O6
MOLECULAR WEIGHT :
289.24
WISWESSER LINE NOTATION :
T56 BVNVJ FNW C- DT6VMVTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
900 mg/kg
SEX/DURATION :
female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 3,987,1964

Safety Information

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Z-Gln-OH
  • Benzyl (2,6-dioxo-3-piperidinyl)carbamate
  • 3-Nitrophthalic anhydride
  • 3-Amino-2,6-piperidinedione hydrochloride
  • 3-aminopiperidine-2,6-dione

DownStream

  • Pomalidomide

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Related Compounds

  • 4-nitrothalidomide
  • 4-Amino-2-chloro-5-(1H-tetrazol-5-yl)benzenesulfonamide
  • 4-(4-Chlorophenyl)-4-Bromopiperide
  • 4-(2-nitroimidazol-1-yl)butane-1,2-diol
  • 4-Iodo-1H-indazole-3-carboxylic acid
  • 4-chlorooxolan-3-ol,formic acid
  • 2-Chloro-5-(4-methylthiophenyl)phenol
  • 4-Amino-N,N-dimethyl-3-trifluoromethyl-benzamide
  • 4-(Methoxymethylene)-1,1-dimethylcyclohexane
  • N-(2-chlorothiazol-5-ylmethyl)-N'-nitrourea
  • 2-Bromo-4-hydrazinylbenzonitrile hydrochloride
  • 2-Fluoro-6-hydrazinylbenzonitrile hydrochloride
  • 2-Ethoxy-1-fluoro-3-methoxybenzene
  • 2-((4-Bromophenyl)amino)-N-(3-methylbutan-2-yl)acetamide
  • 4-Imidazolidinecarboxylic acid, 2-oxo-3-[1-oxo-2-[[3-phenyl-1-[(phenylmethoxy)carbonyl]propyl]amino]propyl]-1-(phenylmethyl)-, 1,1-dimethylethyl ester, [4S-[3[S*(R*)],4R*]]-
  • 1'-(Thiazol-2-yl)spiro[indoline-3,4'-piperidin]-2-one
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