Pomalidomide

Suppliers

Names

[ CAS No. ]:
19171-19-8

[ Name ]:
Pomalidomide

[Synonym ]:
4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-
Pomalidomide
1H-​Isoindole-​1,​3(2H)​-​dione, 4-​amino-​2-​(2,​6-​dioxo-​3-​piperidinyl)​-
Pomalyst
4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide
CC-4047

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
582.9±45.0 °C at 760 mmHg

[ Melting Point ]:
318.5 - 320.5°

[ Molecular Formula ]:
C13H11N3O4

[ Molecular Weight ]:
273.244

[ Flash Point ]:
306.3±28.7 °C

[ Exact Mass ]:
273.074951

[ PSA ]:
109.57000

[ LogP ]:
-0.74

[ Appearance of Characters ]:
yellow

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.691

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: ≥14mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
NR3397905

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Nitrothalidomide
  • 3-Amino-2,6-piperidinedione hydrochloride
  • 3-Aminophthalic acid hydrochloride
  • 3-Nitrophthalic anhydride
  • Z-Gln-OH
  • Benzyl (2,6-dioxo-3-piperidinyl)carbamate

DownStream

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Rational combination treatment with histone deacetylase inhibitors and immunomodulatory drugs in multiple myeloma.

Blood Cancer J. 5 , e312, (2015)

Immunomodulatory drugs (IMiDs) thalidomide, lenalidomide (Len) and pomalidomide trigger anti-tumor activities in multiple myeloma (MM) by targetting cereblon and thereby impacting IZF1/3, c-Myc and IR...

Pomalidomide: evaluation of cytochrome P450 and transporter-mediated drug-drug interaction potential in vitro and in healthy subjects.

J. Clin. Pharmacol. 55(2) , 168-78, (2015)

Pomalidomide offers an alternative for patients with relapsed/refractory multiple myeloma who have exhausted treatment options with lenalidomide and bortezomib. Little is known about pomalidomide's po...

A validated UPLC-MS/MS assay using negative ionization mode for high-throughput determination of pomalidomide in rat plasma.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 983-984 , 76-82, (2015)

In this study, a sensitive UPLC-MS/MS assay was developed and validated for high-throughput determination of pomalidomide in rat plasma using celecoxib as an internal standard (IS). Liquid liquid extr...


More Articles

Related Compounds

  • Pomalidomide-d4
  • Pomalidomide-d5
  • (s)-pomalidomide
  • (R)-pomalidomide
  • Pomalidomide-5-OH
  • Pomalidomide-6-OH
  • 4-[(Benzylamino)methyl]-3,3-difluoropiperidin-4-ol
  • 2-(Aminomethyl)-1-(3-methoxycyclobutyl)butan-1-ol
  • 3-Amino-2-methyl-1-(1,2,2-trimethylcyclopropyl)propan-1-ol
  • 3-(1-Amino-2-methylbutan-2-yl)-1-benzylpyrrolidin-3-ol
  • 3-(1-Aminopropan-2-yl)-1-benzylpiperidin-3-ol
  • 3-(Aminomethyl)-1-(1-aminopropan-2-yl)cyclohexan-1-ol
  • 7-Cyclobutyl-2-ethyl-[1,2,4]triazolo[1,5-a]pyridin-5-ol
  • Tert-butyl 2-amino-1-hydroxy-4-methylcyclohexane-1-carboxylate
  • 2-(ethylamino)-1-[1-(propan-2-yl)-1H-pyrazol-5-yl]ethan-1-ol
  • 1-[1-(2-methylpropyl)-1H-pyrazol-5-yl]-2-[(propan-2-yl)amino]ethan-1-ol
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.