dibenzo[a,e]pyrene
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Names
[ CAS No. ]:
192-65-4
[ Name ]:
dibenzo[a,e]pyrene
[Synonym ]:
Dibenzo[f,pqr]tetraphene
dibenzo(a,e)pyrene
dibenzo[a,e]pyrene
Naphtho[1,2,3,4-def]chrysene
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
552.3±17.0 °C at 760 mmHg
[ Melting Point ]:
233.5ºC
[ Molecular Formula ]:
C24H14
[ Molecular Weight ]:
302.368
[ Flash Point ]:
282.0±15.1 °C
[ Exact Mass ]:
302.109558
[ LogP ]:
7.63
[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.913
[ Storage condition ]:
2-8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QL0175000
- CHEMICAL NAME :
- Naphtho(1,2,3,4-def)chrysene
- CAS REGISTRY NUMBER :
- 192-65-4
- BEILSTEIN REFERENCE NO. :
- 2054070
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C24-H14
- MOLECULAR WEIGHT :
- 302.38
- WISWESSER LINE NOTATION :
- L D66 L666 B6 2AB A&J
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 312 mg/kg/52W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 72 mg/kg/9W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 25 nmol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 342,9,1995 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 3,201,1973 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 32,327,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 32,327,1983 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FRANCE;Carcinogen JAN 1993
Safety Information
[ Symbol ]:
GHS05, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H341-H350
[ Precautionary Statements ]:
P201-P202-P281-P308 + P313-P405-P501
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
40-41
[ Safety Phrases ]:
26-39
[ RIDADR ]:
UN 2811
[ RTECS ]:
QL0175000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2902909090
Synthetic Route
Customs
[ HS Code ]: 2902909090
[ Summary ]:
2902909090 other aromatic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%
Articles
Rep. Carcinog. 12 , 353-61, (2011)
Int. J. Environ. Anal. Chem. 19(2) , 111-31, (1985)
Twenty-three polycyclic aromatic hydrocarbons (PAH) were determined in atmospheric particulate matter in 4 places of the Paris area at several times of the year. Fractionation was performed by reverse...
IARC Monogr. Eval. Carcinog. Risk Chem. Hum. 32 , 327-30, (1983)