Lomeguatrib

Suppliers

Names

[ CAS No. ]:
192441-08-0

[ Name ]:
Lomeguatrib

[Synonym ]:
Lomeguatrib
UNII-S79265T71M
2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine O6-(4-bromothenyl)guanine
6-[(4-bromothiophen-2-yl)methoxy]-7H-purin-2-amine
6-[(4-Bromo-2-thienyl)methoxy]-7H-purin-2-amine
7H-Purin-2-amine, 6-[(4-bromo-2-thienyl)methoxy]-

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
683.8±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₈BrN₅OS

[ Molecular Weight ]:
326.172

[ Flash Point ]:
367.3±34.3 °C

[ Exact Mass ]:
324.963287

[ PSA ]:
117.95000

[ LogP ]:
2.36

[ Appearance of Characters ]:
white to beige

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.797

[ Storage condition ]:
room temp

[ Water Solubility ]:
DMSO: soluble10mg/mL, clear

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
UO7420000

Precursor & DownStream

Precursor

(4-Bromo-2-thienyl)methanol
2-amino-N,N,N-trimethyl-9H-purine-6-ylammonium chloride
4-Bromthiophen-2-carbaldehyd

DownStream

Articles

Effect of lomeguatrib-temozolomide combination on MGMT promoter methylation and expression in primary glioblastoma tumor cells.

Tumour Biol. 34(3) , 1935-47, (2013)

Temozolomide (TMZ) is commonly used in the treatment of glioblastoma (GBM). The MGMT repair enzyme (O (6)-methylguanine-DNA methyltransferase) is an important factor causing chemotherapeutic resistanc...

Randomized trial of the combination of lomeguatrib and temozolomide compared with temozolomide alone in chemotherapy naive patients with metastatic cutaneous melanoma.

J. Clin. Oncol. 25(18) , 2540-5, (2007)

To evaluate tumor response, pharmacodynamic effects, and safety of a combination of lomeguatrib (LM), an O6-methylguanine DNA-methyltransferase (MGMT) inactivator, and temozolomide (TMZ), TMZ alone, a...

[Analysis of the relevant factors of mechanism for telozolomide chemoresistance].

Zhonghua Zhong Liu Za Zhi 33(10) , 794-6, (2011)

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