11α-Hydroxy Mexrenone

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Names

[ CAS No. ]:
192704-56-6

[ Name ]:
11α-Hydroxy Mexrenone

[Synonym ]:
W4125
11-A-Hydroxy canrenone methyl ester
11alpha-Hydroxymexrenone
methyl (7R,8S,9S,10R,11R,13S,14S,17R)-11-hydroxy-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-carboxylate
Eplerenone Intermediate
Eplerenone Impurity 5

Chemical & Physical Properties

[ Melting Point ]:
230-232°C

[ Molecular Formula ]:
C24H32O6

[ Molecular Weight ]:
416.50700

[ Exact Mass ]:
416.22000

[ PSA ]:
89.90000

[ LogP ]:
2.96400

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (Trimethylsilyl)diazomethane
  • methyl iodide
  • 4'S(4'α),7'α-hexadecahydro-11'α-hydroxy-10'β,13'beta-dimethyl-3',5,20'-trioxospiro[furan-2(3H),17'β-[4,7]metheno(17H)cyclopenta[a]phenanthrene]-5'β(2'H)-carbonitrile
  • Sodium Methylate
  • Potassium methoxide
  • Mexrenone
  • 11α-Hydroxy Canrenone
  • 11β,17β-dihydroxy-7β-nitromethyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone

DownStream

  • 9,11-Eplerenone
  • Eplerenone

Related Compounds

  • 11α-hydroxy-5α-androstane-3,17-dione
  • 11α-hydroxy-12-oxo-5β-cholan-24-oic acid methyl ester
  • 11α-Hydroxy-2-methoxypicras-2-ene-1,12,16-trione
  • 11α-Hydroxy-2,12β-dimethoxypicras-2-ene-1,16-dione
  • 11α-Hydroxy-23-norconanine-1,4,18(22)-trien-3-one
  • 11α-Hydroxy-25D-spirosta-1,4-dien-3-on-acetat