Lonafarnib

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Names

[ CAS No. ]:
193275-84-2

[ Name ]:
Lonafarnib

[Synonym ]:
1-PiperidinecarboxaMide,4-[2-[4-[(11R)-3,10-dibroMo-8-chloro-6
4-{2-[4-(3,10-dibromo-8-chloro-6,l l-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide
Lonafarnib
4-{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide
4-[2-[4-[(11R)-3,10-DibroMo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1
[14C]-Lonafarnib
LonafarMib
4-(2-{4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl}-2-oxoethyl)-1-piperidinecarboxamide
Lonafarnib [usan]
(+)-4-[2-[4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-[5,6]cyclohepta[1,2-b]-pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyt]-1-piperidinecarboxamide
Sarasar
1-Piperidinecarboxamide, 4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
710.4±70.0 °C at 760 mmHg

[ Melting Point ]:
214.5-215.9° (monohydrate); mp 222-223°

[ Molecular Formula ]:
C27H31Br2ClN4O2

[ Molecular Weight ]:
638.822

[ Flash Point ]:
383.5±35.7 °C

[ Exact Mass ]:
636.050232

[ PSA ]:
79.53000

[ LogP ]:
5.03

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.630

[ Storage condition ]:
-20℃

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

Precursor & DownStream

Precursor

  • trimethylsilyl isocyanate
  • Urea
  • 1-Boc-4-piperidylacetic acid
  • 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 3,10-dibromo-8-chloro-6,11-dihydro-11-(4-piperidinyl)-, (11R)-
  • (+)-1,1-dimethylethyl[[[4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-carbonyl]-methyl]-1-piperidinecarboxylate
  • 4-[3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo-[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidine
  • 4-[3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo-[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidinecarboxylic acid ethyl ester

DownStream

Related Compounds

  • LONAFARNIB
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • 2-(methylsulfanyl)-N-{4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]phenyl}pyridine-3-carboxamide
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • N-(sec-butyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]quinoline-2-carboxamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine