TAS 301

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Names

[ CAS No. ]:
193620-69-8

[ Name ]:
TAS 301

[Synonym ]:
TAS-301
3-[Bis(4-methoxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one
2H-Indol-2-one, 3-[bis(4-methoxyphenyl)methylene]-1,3-dihydro-
IN1440
3-Bis-(4-methoxphenyl)methylene-2-indolinone
3-bis(4-Methoxyphenyl)methylene-2-indolinone

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
573.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₁₉NO₃

[ Molecular Weight ]:
357.402

[ Flash Point ]:
300.5±30.1 °C

[ Exact Mass ]:
357.136505

[ PSA ]:
47.56000

[ LogP ]:
4.72

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.630

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries.

J. Pharmacol. Exp. Ther. 285 , 1280-1286, (1998)

The purpose of this study was to determine the efficacy and the possible mechanism of action of a recently synthesized drug, TAS-301 [3-bis (4-methoxyphenyl)methylene-2-indolinone], on intimal formati...

TAS-301 blocks receptor-operated calcium influx and inhibits rat vascular smooth muscle cell proliferation induced by basic fibroblast growth factor and platelet-derived growth factor.

Jpn. J. Pharmacol. 84(3) , 252-8, (2000)

The purpose of this study was to determine the effect of a recently synthesized drug, TAS-301 [3-bis(4-methoxyphenyl)methylene-2-indolinone], on vascular smooth muscle cell (VSMC) proliferation and th...

Tas-301, a new synthetic inhibitor of neointimal thickening after balloon injury, inhibits calcium-dependent signal transduction and cytoskeletal reorganization.

Pharmacology 63 , 17-27, (2001)

We previously demonstrated that a recently synthesized drug, TAS-301 [3-bis(4-methoxyphenyl)methylene-2-indolinone], inhibited neointimal thickening after single-balloon injury to the rat common carot...

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