Benzo[c]chrysene

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Names

[ CAS No. ]:
194-69-4

[ Name ]:
Benzo[c]chrysene

[Synonym ]:
1,2:5,6-Dibenzophenanthrene
benz<c>chrysene
Benzo[c]chrysene
1,2,5,6-Dibenzphenanthrene

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
524.7±17.0 °C at 760 mmHg

[ Melting Point ]:
126.5°C

[ Molecular Formula ]:
C22H14

[ Molecular Weight ]:
278.347

[ Flash Point ]:
264.5±15.1 °C

[ Exact Mass ]:
278.109558

[ LogP ]:
7.14

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.812

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DE7350000
CHEMICAL NAME :
Benzo(c)chrysene
CAS REGISTRY NUMBER :
194-69-4
BEILSTEIN REFERENCE NO. :
1876196
LAST UPDATED :
199710
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C22-H14
MOLECULAR WEIGHT :
278.36
WISWESSER LINE NOTATION :
L F6 C6 B666J

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1630 mg/kg/68W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
REFERENCE :
PRLBA4 Proceedings of the Royal Society of London, Series B: Biological Sciences. (Royal Soc., 6 Carlton House Terrace, London SW1Y 5AG, UK) V.76- 1905- Volume(issue)/page/year: 129,439,1940
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2400 mg/kg/36W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
REFERENCE :
PRLBA4 Proceedings of the Royal Society of London, Series B: Biological Sciences. (Royal Soc., 6 Carlton House Terrace, London SW1Y 5AG, UK) V.76- 1905- Volume(issue)/page/year: 129,439,1940

Safety Information

[ HS Code ]:
2902909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,3-Bis[(E)-styryl]benzene
  • 4-phenethyl-1,2-dihydro-phenanthrene
  • Carbon disulphide
  • Aluminium chloride

DownStream

Customs

[ HS Code ]: 2902909090

[ Summary ]:
2902909090 other aromatic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

Articles

Covalent DNA adducts formed by benzo[c]chrysene in mouse epidermis and by benzo[c]chrysene fjord-region diol epoxides reacted with DNA and polynucleotides.

Chem. Res. Toxicol. 10(11) , 1275-84, (1997)

The metabolic activation in mouse skin of benzo[c]chrysene (B[c]C), a weakly carcinogenic polycyclic aromatic hydrocarbon (PAH) present in coal tar and crude oil, was investigated. Male Parkes mice we...

Metabolism of benzo[c]chrysene and comparative mammary gland tumorigenesis of benzo[c]chrysene bay and fjord region diol epoxides in female CD rats.

Chem. Res. Toxicol. 16(2) , 227-31, (2003)

Benzo[c]chrysene (BcC), an environmental pollutant, is a unique polycyclic aromatic hydrocarbon that possesses both a bay region and a fjord region in the same molecule. We previously demonstrated tha...

Synthesis of fjord region tetraols and their use in hepatic biotransformation studies of dihydrodiols of benzo[c]chrysene, benzo[g]chrysene and dibenzo[a,l]pyrene.

Carcinogenesis 19(4) , 639-48, (1998)

Metabolic activation of the racemic benzo[c]chrysene-trans-9,10-, benzo[g]chrysene-trans-11,12- and dibenzo[a,l]pyrene-trans-11,12-dihydrodiols to fjord region syn- and anti-dihydrodiol epoxides by mi...


More Articles

Related Compounds

  • BENZO[C]CHRYSENE-TRANS-9,10-DIHYDRODIOL
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  • benzo(c)phenanthrene 5,6-dihydrodiol
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  • tert-butyl N-{2-[5-(hydroxymethyl)-1,3,4-thiadiazol-2-yl]ethyl}carbamate
  • 4-[(3-Bromo-2-methylphenyl)methyl]piperidin-4-ol
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