Metrizoic acid

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Names

[ CAS No. ]:
1949-45-7

[ Name ]:
Metrizoic acid

[Synonym ]:
3-Acetamido-2,4,6-triiodo-5-(N-methylacetamido)benzoic acid
Metrizoic acid
metrizoate
3-Acetamido-5-(N-methylacetamido)-2,4,6-triiodobenzoic Acid
3,5-DiacetaMido-N-Methyl-2,4,6-triiodobenzoic Acid
Metrizoic
Metrizoesaeure
MFCD00867964
Triosil-280
5-Acetamino-3-<N-acetyl-methylamino>-2.4.6-triiod-benzoesaeure
EINECS 217-761-1

Chemical & Physical Properties

[ Density]:
2.483g/cm3

[ Boiling Point ]:
678.8ºC at 760mmHg

[ Molecular Formula ]:
C12H11I3N2O4

[ Molecular Weight ]:
627.94000

[ Flash Point ]:
364.3ºC

[ Exact Mass ]:
627.78500

[ PSA ]:
86.71000

[ LogP ]:
3.21270

[ Vapour Pressure ]:
2.35E-19mmHg at 25°C

[ Index of Refraction ]:
1.77

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DG0887300
CHEMICAL NAME :
Benzoic acid, 3-acetamido-2,4,6-triiodo-5-(N-methylacetamido)-
CAS REGISTRY NUMBER :
1949-45-7
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C12-H11-I3-N2-O4
MOLECULAR WEIGHT :
627.95
WISWESSER LINE NOTATION :
1VN1&R BI DI FI CVQ EMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
38100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
29600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
14300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>46800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
36 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 17,340,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intracerebral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
234 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982

Safety Information

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26-S36/37/39

[ RTECS ]:
DG0887300

[ HS Code ]:
2924299090

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • metrizoic acid sodium salt
  • Octanethioic acid S-propyl ester
  • Hexanethioic acid S-decyl ester
  • Thiopropionic acid S-undecyl ester
  • trisporic acid
  • Benzenesulfonic acid, 3,3-methylenebis2,4(or 4,6)-dihydroxyphenyleneazobis-, potassium sodium salt
  • 2-[4-(6-bromo-5,7-dimethyl-1,8-naphthyridin-2-yl)piperazin-1-yl]-N-(propan-2-yl)propanamide
  • 4-Ethyl-2-(4-{imidazo[1,2-b]pyridazin-6-yl}piperazin-1-yl)-1,3-benzothiazole
  • 3-[2-[(3,5-Dimethyl-1,2-oxazol-4-yl)methyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-1,2-benzothiazole 1,1-dioxide
  • 1-{2-[4-(6-Cyclopropyl-1,8-naphthyridin-2-yl)piperidin-1-yl]-2-oxoethyl}pyrrolidine-2,5-dione
  • 3-[2-(1,2,4-Oxadiazol-3-ylmethyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-1,2-benzothiazole 1,1-dioxide
  • 2-(4-{imidazo[1,2-b]pyridazin-6-yl}piperazin-1-yl)-1H-1,3-benzodiazole
  • N-[1-(3-bromo-5-chloropyridin-2-yl)piperidin-3-yl]-N-methylcyclopropanesulfonamide
  • N-cyclopentyl-2-[3-(N-methylcyclopropanesulfonamido)piperidin-1-yl]acetamide
  • N-cyclopropyl-4-({[3-(trifluoromethyl)phenyl]carbamoyl}methyl)morpholine-2-carboxamide
  • 2-(4-{Imidazo[1,2-b]pyridazin-6-yl}-1,4-diazepan-1-yl)-4,6-dimethyl-1,3-benzothiazole
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