Galantamine hydrobromide

Suppliers

Names

[ CAS No. ]:
1953-04-4

[ Name ]:
Galantamine hydrobromide

[Synonym ]:
(4aS,6R,8aS)-3-Methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-olhydrobromid
NIVALIN,HBR
MFCD00067672
(4aS,6R,8aS)-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide
(4aS,6R,8aS)-3-méthoxy-11-méthyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazépin-6-ol bromhydrate
Galanthamine hydrobromide (1:1)
GALANTHAMIDE HYDROBROMIDE
[3H]-Galantamine hydrobromide
UNII:5N4SA4KQX9
galanthamine bromhydrate (1:1)
Galantamine hydrobromide (JAN/USAN)
Galanthamine HBr
Galanthamine (hydrobromide)
Galantamine hydrobromide
(-)-Galanthaminium bromide
NIVALIN
6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aS,6R,8aS)-, hydrobromide (1:1)
galanthaminhydrobromid(1:1)
GALANTHAMINE HYDROBROMIDUM
EINECS 217-780-5
GALANTAMINE HBR
6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aS,6R,8aS)-, hydrobromide

Chemical & Physical Properties

[ Melting Point ]:
256 °C

[ Molecular Formula ]:
C₁₇H₂₂BrNO₃

[ Molecular Weight ]:
368.266

[ Exact Mass ]:
367.078308

[ PSA ]:
41.93000

[ LogP ]:
2.74630

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
-95 ° (C=1.4, H2O)

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T

[ Risk Phrases ]:
R25:Toxic if swallowed.

[ Safety Phrases ]:
45-36/37/39-22

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
DF8075000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Galanthaminone
Galantamine
(-)-galantamine tartarate
N-(p-Hydroxyphenethyl)-N-(2-bromo-5-hydroxy-4-methoxybenzyl)formamide
2-Bromo-4,5-dimethoxybenzaldehyde
veratraldehyde
2-Bromoisovanillin
4-bromo-5-((4-hydroxyphenethylamino)Methyl)-2-Methoxyphenol

DownStream

Articles

Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity.

J. Chromatogr. A. 1374 , 122-33, (2014)

The present study investigated the practical use of modern ultra-high performance liquid chromatography (UHPLC) separation techniques for drug metabolite profiling, aiming to develop a widely applicab...

Galantamine-loaded PLGA nanoparticles, from nano-emulsion templating, as novel advanced drug delivery systems to treat neurodegenerative diseases.

Nanoscale 7 , 12076-84, (2015)

Polymeric nanoparticles could be promising drug delivery systems to treat neurodegenerative diseases. Among the various methods of nanoparticle preparation, nano-emulsion templating was used in the pr...

Acetylcholine excites neocortical pyramidal neurons via nicotinic receptors.

J. Neurophysiol. 113 , 2195-209, (2015)

The neuromodulator acetylcholine (ACh) shapes neocortical function during sensory perception, motor control, arousal, attention, learning, and memory. Here we investigate the mechanisms by which ACh a...