3-Oxidido 17-alpha-ethynyl 17-beta-hydroxy estra-4,9,11-triene [French ]

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Names

[ CAS No. ]:
19636-23-8

[ Name ]:
3-Oxidido 17-alpha-ethynyl 17-beta-hydroxy estra-4,9,11-triene [French ]

[Synonym ]:
R 2010 oxime
Oxime,17-hydroxy-19-norpregna-4,9,11-trien-20-yn-3-one
So 57

Chemical & Physical Properties

[ Density]:
1.244g/cm3

[ Boiling Point ]:
533.233ºC at 760 mmHg

[ Molecular Formula ]:
C20H23NO2

[ Molecular Weight ]:
309.40200

[ Flash Point ]:
358.8ºC

[ Exact Mass ]:
309.17300

[ PSA ]:
52.82000

[ LogP ]:
3.59380

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.643

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RC8960090
CHEMICAL NAME :
19-Norpregna-4,9,11-trien-20-yn-3-one, 17-hydroxy-, oxime, (17-alpha)-
CAS REGISTRY NUMBER :
19636-23-8
LAST UPDATED :
199712
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C20-H23-N-O2
MOLECULAR WEIGHT :
309.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
22 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #4826M ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2 mg/kg
SEX/DURATION :
female 6-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980- Volume(issue)/page/year: 10(3),67,1990

Related Compounds

  • Propan-2-yl 4-[(4-bromophenyl)amino]-7-methyl-1,8-naphthyridine-3-carboxylate
  • 2-Amino-N-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)benzamide hydrochloride
  • Propan-2-yl 4-[(2,3-dihydro-1,4-benzodioxin-6-yl)amino]-7-methyl-1,8-naphthyridine-3-carboxylate
  • Propan-2-yl 4-[(3,5-dimethoxyphenyl)amino]-7-methyl-1,8-naphthyridine-3-carboxylate
  • Isopropyl 7-methyl-4-((4-sulfamoylphenyl)amino)-1,8-naphthyridine-3-carboxylate
  • Propan-2-yl 4-[(4-iodophenyl)amino]-7-methyl-1,8-naphthyridine-3-carboxylate
  • Isopropyl 4-((3-bromophenyl)amino)-7-methyl-1,8-naphthyridine-3-carboxylate
  • Isopropyl 4-((4-chloro-2,5-dimethoxyphenyl)amino)-7-methyl-1,8-naphthyridine-3-carboxylate
  • Propan-2-yl 7-methyl-4-{[3-(trifluoromethoxy)phenyl]amino}-1,8-naphthyridine-3-carboxylate
  • Propan-2-yl 4-[(4-methanesulfonylphenyl)amino]-7-methyl-1,8-naphthyridine-3-carboxylate
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