4-(4-bromo-2-fluorophenylamino)-6-methoxyquinazolin-7-ol

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Names

[ CAS No. ]:
196603-96-0

[ Name ]:
4-(4-bromo-2-fluorophenylamino)-6-methoxyquinazolin-7-ol

[Synonym ]:
7-quinazolinol, 4-[(4-bromo-2-fluorophenyl)amino]-6-methoxy-
4-[(4-Bromo-2-fluorophenyl)amino]-6-methoxyquinazolin-7-ol
4-[(4-Bromo-2-fluorophenyl)amino]-6-methoxy-7-quinazolinol
qc-1062

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
471.0±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H11BrFN3O2

[ Molecular Weight ]:
364.169

[ Flash Point ]:
238.6±28.7 °C

[ Exact Mass ]:
363.001862

[ PSA ]:
67.27000

[ LogP ]:
3.99

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.714

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine
  • 4-Bromo-2-fluoroaniline
  • 2-amino-5-methoxy-4-phenylmethoxybenzamide
  • 7-(benzyloxy)-6-methoxyquinazolin-4-ol
  • 4-(Benzyloxy)-5-methoxy-2-nitrobenzoic acid
  • 4-(BENZYLOXY)-5-METHOXY-2-NITROBENZALDEHYDE
  • 5-methoxy-2-nitro-4-phenylmethoxybenzamide
  • 4-(Benzyloxy)-3-methoxybenzaldehyde
  • 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline
  • 4-hydroxy-6-methoxyquinazolin-7-yl benzoate

DownStream

  • Vandetanib(ZD6474)
  • TERT-BUTYL 4-(((4-((4-BROMO-2-FLUOROPHENYL)AMINO)-6-METHOXYQUINAZOLIN-7-YL)OXY)METHYL)PIPERIDINE-1-CARBOXYLATE
  • N-DeMethyl Vandetanib

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%