(S)-10-Hydroxycamptothecin

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Names

[ CAS No. ]:
19685-09-7

[ Name ]:
(S)-10-Hydroxycamptothecin

[Synonym ]:
10-Hydroxycamptothecin
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (4S)-
Hydroxycamptothecine
10-Hydroxy camptothecin
10-OH-camptothecin
10-hydroxy-CPT
Camptothecin,hydroxy
MFCD00189425
10-Hydroxycamptochecin
Camptothecin, 10-hydroxy
10-hydroxy-Camptothecin
(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Hydroxycamptothecin
10-hydroxycamptothecine
Irinotecan Related Compound A
HCPT
(S)-10-Hydroxycamptothecin

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
820.7±65.0 °C at 760 mmHg

[ Melting Point ]:
265-270°C

[ Molecular Formula ]:
C20H16N2O5

[ Molecular Weight ]:
364.351

[ Flash Point ]:
450.1±34.3 °C

[ Exact Mass ]:
364.105927

[ PSA ]:
101.65000

[ LogP ]:
1.32

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.777

[ Storage condition ]:
-20°C Freezer

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UQ0491700
CAS REGISTRY NUMBER :
19685-09-7
LAST UPDATED :
198305
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C20-H16-N2-O5.H2-O
MOLECULAR WEIGHT :
382.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
104 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Cells - not otherwise specified
DOSE/DURATION :
100 ug/L
REFERENCE :
YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year: 21,492,1986

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Campathecin
  • (4S)-4-Ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • 1,2,6,7-tetrahydro-(20S)-camphthotecine
  • (S)-10-((Dimethylamino)methyl)-4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl acetate
  • (S)-4-ethyl-4-hydroxy-6-iodo-3-oxo-1H-pyrano[3,4-c]-8-pyridone
  • Camptothecin N-oxide
  • Ethylsulfanylacetat

DownStream

  • rubitecan
  • 9-Aminocamptothecin
  • 7-Ethyl-10-hydroxycamptothecin
  • (4S)-4-Ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • 9-Nitro-10-hydroxy camptothecin
  • Topotecan hydrochloride hydrate
  • Topotecan hydrochloride

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • (S)-10-hydroxycamptothecin
  • (S)-10-Hydroxycamptothecin-d5
  • Chimmitecan
  • (S)-9-(4-METHYL-1-PIPERAZINYL)METHYL-10-HYDROXYCAMPTOTHECIN
  • (S)-10-amino-1,2,3-trimethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-one
  • (S)-(-)-10,10'-dihydroxy-9,9'-biphenanthryl