PQ 401

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Names

[ CAS No. ]:
196868-63-0

[ Name ]:
PQ 401

[Synonym ]:
1-(5-Chloro-2-methoxyphenyl)-3-(2-methyl-4-quinolinyl)urea
IGF-1R Inhibitor II
UNII-2N3LV83S8J
1-(5-Chloro-2-methoxyphenyl)-3-(2-methylquinolin-4-yl)urea
TCMDC-125497
N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)
Urea, N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-
PQ 401
PQ401

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
426.1±45.0 °C at 760 mmHg

[ Melting Point ]:
190 °C(dec.)

[ Molecular Formula ]:
C₁₈H₁₆ClN₃O₂

[ Molecular Weight ]:
341.792

[ Flash Point ]:
211.5±28.7 °C

[ Exact Mass ]:
341.093109

[ PSA ]:
63.25000

[ LogP ]:
5.35

[ Appearance of Characters ]:
white

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.709

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: >10mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R25

[ Safety Phrases ]:
S45

[ RIDADR ]:
UN 2811 6.1/PG 3

[ HS Code ]:
2933499090

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Identification of Novel IGF1R Kinase Inhibitors by Molecular Modeling and High-Throughput Screening.

Acta Naturae 5(2) , 90-9, (2013)

The aim of this study was to identify small molecule compounds that inhibit the kinase activity of the IGF1 receptor and represent novel chemical scaffolds, which can be potentially exploited to devel...

IGFBP-2 directly stimulates osteoblast differentiation.

J. Bone Miner Res. 29(11) , 2427-38, (2014)

Insulin-like growth factor binding protein 2 (IGFBP-2) is important for acquisition of normal bone mass in mice; however, the mechanism by which IGFBP-2 functions is not defined. These studies investi...

Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth.

Mol. Cancer Ther. 5 , 1079-1086, (2006)

In breast and certain other cancers, receptor tyrosine kinases, including the insulin-like growth factor I receptor (IGF-IR), play an important role in promoting the oncogenic process. The IGF-IR is t...