11-[3-(methylamino)propyl]-5,6-dihydrobenzo[b][1]benzazepin-3-ol

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Names

[ CAS No. ]:
1977-15-7

[ Name ]:
11-[3-(methylamino)propyl]-5,6-dihydrobenzo[b][1]benzazepin-3-ol

[Synonym ]:
5-[3-(Methylamino)propyl]-10,11-dihydro-5H-dibenzo[b,f]azepin-2-ol
5H-Dibenz(b,f)azepin-2-ol,10,11-dihydro-5-(3-(methylamino)propyl)
2-Hydroxydesmethylimipramine
2-hydroxy-desipramine
10,11-Dihydro-5-(3-(methylamino)propyl)-5H-dibenz(b,f)azepin-2-ol

Chemical & Physical Properties

[ Density]:
1.117g/cm3

[ Boiling Point ]:
477.9ºC at 760mmHg

[ Melting Point ]:
146-148ºC

[ Molecular Formula ]:
C18H22N2O

[ Molecular Weight ]:
282.38000

[ Flash Point ]:
242.8ºC

[ Exact Mass ]:
282.17300

[ PSA ]:
35.50000

[ LogP ]:
3.69430

[ Vapour Pressure ]:
9.32E-10mmHg at 25°C

[ Index of Refraction ]:
1.596

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HO2990000
CHEMICAL NAME :
5H-Dibenz(b,f)azepin-2-ol, 10,11-dihydro-5-(3-(methylamino)propyl)-
CAS REGISTRY NUMBER :
1977-15-7
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C18-H22-N2-O
MOLECULAR WEIGHT :
282.42
WISWESSER LINE NOTATION :
T C676 BN&T&J B3M1 FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
31 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 15,187,1966

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N-Benzyl-2-hydroxydesipramine
  • N-Benzyl-3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-Methylpropan-1-amine
  • Desipramine hydrochloride
  • N-Benzyl-2-formyldesipramine

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%