2-amino-4-(S-methylsulphonimidoyl)butyric acid

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Names

[ CAS No. ]:
1982-67-8

[ Name ]:
2-amino-4-(S-methylsulphonimidoyl)butyric acid

[Synonym ]:
methionine sulphoximine
methioninesulfoximine
Methioninsulfoximin
Methionin-S-imid-S-oxid
DL-METHIONINE SULFOXIMINE
L-METHIONINE-RS-SULPHOXIMINE
dl-methionine-dl-sulfoximin
DL-METHIONINE DL-SULFOXIMINE
DL-(3-Amino-3-carboxypropyl) methyl sulfoximine
CNESTINE
dl-sulfoximin
AURORA KA-705
METHIONINESULPHOXIME
methionine S-imide-S-oxide
DL-LOBAMINE-DL-SULFOXIMINE

Chemical & Physical Properties

[ Density]:
1.46g/cm3

[ Boiling Point ]:
352.2ºC at 760mmHg

[ Molecular Formula ]:
C5H12N2O3S

[ Molecular Weight ]:
180.22500

[ Flash Point ]:
166.8ºC

[ Exact Mass ]:
180.05700

[ PSA ]:
112.62000

[ LogP ]:
1.13070

[ Vapour Pressure ]:
6.63E-06mmHg at 25°C

[ Index of Refraction ]:
1.559

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WS3560000
CHEMICAL NAME :
Sulfoximine, S-(3-amino-3-carboxypropyl)-S-methyl-, DL-
CAS REGISTRY NUMBER :
1982-67-8
LAST UPDATED :
199206
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C5-H12-N2-O3-S
MOLECULAR WEIGHT :
180.25
WISWESSER LINE NOTATION :
QVYZ2S1&UM -DL

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
218 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 94,12,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03652 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
350 mg/kg
SEX/DURATION :
female 9-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
ASMUAA Acta Scholae Medicinalis Universitatis in Kioto. (Kyoto, Japan) V.27-40, 1947-70. Discontinued. Volume(issue)/page/year: 38,193,1962
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
3500 mg/kg
SEX/DURATION :
female 9-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
ASMUAA Acta Scholae Medicinalis Universitatis in Kioto. (Kyoto, Japan) V.27-40, 1947-70. Discontinued. Volume(issue)/page/year: 38,193,1962

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ WGK Germany ]:
3

[ RTECS ]:
WS3560000

[ HS Code ]:
2925290090

Customs

[ HS Code ]: 2925290090

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%


Related Compounds

  • L-homocystine dimethyl ester
  • H-Daba(Boc)-OH
  • D-GSH
  • 2-Amino-4-(S-methylsulfonimidoyl)butanoic acid
  • 2-amino-4-phenoxybutanoic acid
  • 2-amino-4-[2-(3-amino-3-carboxy-propyl)sulfanylethylsulfanyl]butanoic acid
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 2-[2-(diethylamino)ethyl]-1-(3,4-dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydro-1H-chromeno[2,3-c]pyrrole-3,9-dione
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • tert-Butyl 4-(((3-methylpyrazin-2-yl)sulfonyl)methyl)piperidine-1-carboxylate
  • (4-cyclopropyl-5-methyl-4H-1,2,4-triazol-3-yl)methanol
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde