Bazedoxifene

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Names

[ CAS No. ]:
198481-32-2

[ Name ]:
Bazedoxifene

[Synonym ]:
TSE-424
Bazedoxifene
1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-
1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-indol-5-ol
1-{4-[2-(Azepan-1-yl)ethoxy]benzyl}-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol
Bazedoxifeno
1-{4-[2-(1-Azepanyl)ethoxy]benzyl}-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol
1H-Indol-5-ol, 1-((4-(2-(hexahydro-1H-azepin-1-yl)ethoxy)phenyl)methyl)-2-(4-hydroxyphenyl)-3-methyl-
Conbriza

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
694.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H34N2O3

[ Molecular Weight ]:
470.603

[ Flash Point ]:
373.8±31.5 °C

[ Exact Mass ]:
470.256958

[ PSA ]:
57.86000

[ LogP ]:
6.59

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.622

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-[4-(2-AZEPAN-1-YL-ETHOXY)-BENZYL]-5-BENZYLOXY-2-(4-BENZYLOXY-PHENYL)-3-METHYL-1H-INDOLE
  • Adipaldehyde
  • Azepane
  • 4-Hydroxybenzyl alcohol
  • 4'-(Benzyloxy)-2-bromopropiophenone
  • 3-methyl-5-phenylmethoxy-2-(4-phenylmethoxyphenyl)-1H-indole
  • 4-Benzyloxyaniline Hydrochloride

DownStream

Related Compounds

  • Bazedoxifene
  • Bazedoxifene-d4
  • Bazedoxifene HCl
  • Bazedoxifene N-Oxide
  • Bazedoxifene Acetate
  • Bazedoxifene-d4 N-Oxide
  • (3S)-3-{[(tert-butoxy)carbonyl]amino}-3-(3-methyl-1,2-thiazol-5-yl)propanoic acid
  • methyl (3S)-3-amino-3-(3,3-dimethylcyclobutyl)propanoate
  • (3R)-3-{[(benzyloxy)carbonyl]amino}-3-(5-methylthiophen-3-yl)propanoic acid
  • (3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(3-methoxycyclobutyl)propanoic acid
  • 3-{[(Tert-butoxy)carbonyl]amino}-3-(1,2-dimethylcyclopropyl)propanoic acid
  • (3R)-3-{[(tert-butoxy)carbonyl]amino}-3-(2,2-dimethylcyclopropyl)propanoic acid
  • (3R)-3-(1-ethyl-1H-1,2,3-triazol-4-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
  • (3S)-3-{[(tert-butoxy)carbonyl]amino}-3-{spiro[2.2]pentan-1-yl}propanoic acid
  • 3-{[(Tert-butoxy)carbonyl]amino}-3-(3,3-dimethylcyclobutyl)propanoic acid
  • 2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-1-methylpyrrolidin-3-yl]acetic acid
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