O6-Benzylguanine

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Names

[ CAS No. ]:
19916-73-5

[ Name ]:
O6-Benzylguanine

[Synonym ]:
O(6)-Benzylguanine
7H-purin-2-amine, 6-(phenylmethoxy)-
O6-Benzylguanine
2-amino-6-(phenylmethoxy)-9H-purine
O(6)-bGua
2-Amino-6-benzyloxy-9H-purine
O-6-Benzylguanine
6-Benzyloxy guanine
6-(Benzyloxy)-3H-purin-2-amine
2-Amino-6-(benzyloxy)purine
6-O-Benzylguanine
9H-Purin-2-amine, 6-(phenylmethoxy)-
6-(benzyloxy)guanine
O-Benzylguanine
6-(phenylmethoxy)-9H-purin-2-amine
MFCD00269931
amino-6-(phenylmethoxy)-9H-purine
6-(Benzyloxy)-7H-purin-2-amine

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
621.4±63.0 °C at 760 mmHg

[ Melting Point ]:
193(dec.)

[ Molecular Formula ]:
C12H11N5O

[ Molecular Weight ]:
241.249

[ Flash Point ]:
329.6±33.7 °C

[ Exact Mass ]:
241.096359

[ PSA ]:
89.71000

[ LogP ]:
1.95

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.743

[ Storage condition ]:
-20°C Freezer

[ Water Solubility ]:
methanol: 20 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

  • 2-Amino-6-chloropurine
  • Benzyl alcohol
  • 2-amino-6-benzyloxypurine methanolate
  • 2-amino-N,N,N-trimethyl-9H-purine-6-ylammonium chloride
  • SODIUM BENZYLOXIDE
  • 2-Benzyloxy-5-(2'-p-toluenesulfonyl-oxyethyl)-2-oxo-1,3,2-dioxaphosphorinane
  • (6-(benzyloxy)-2-((((4-nitrobenzyl)oxy)carbonyl)amino)-9H-purin-9-yl)methyl pivalate
  • 4-nitrobenzyl (6-(benzyloxy)-9H-purin-2-yl)carbamate

DownStream

  • Benzyl(phenyl)sulfane
  • Guanine
  • (1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol
  • Iso Ganciclovir
  • N-(6-phenylmethoxy-7H-purin-2-yl)acetamide

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Differential expression of miR200a-3p and miR21 in grade II-III and grade IV gliomas: evidence that miR200a-3p is regulated by O⁶-methylguanine methyltransferase and promotes temozolomide responsiveness.

Cancer Biol. Ther. 15(7) , 938-50, (2014)

Glioblastoma multiforme (GBM) is the most common primary brain tumor and is among the deadliest of human cancers. Dysregulation of microRNAs (miRNAs) expression is an important step in tumor progressi...

Formation and repair of pyridyloxobutyl DNA adducts and their relationship to tumor yield in A/J mice.

Chem. Res. Toxicol. 25(10) , 2167-78, (2012)

The nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a known human carcinogen. It generates methyl and pyridyloxobutyl DNA adducts. The role of the methyl DNA adducts has been well-...

Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth.

Mol. Cancer Ther. 14(1) , 111-9, (2015)

The cellular responses to two new temozolomide (TMZ) analogues, DP68 and DP86, acting against glioblastoma multiforme (GBM) cell lines and primary culture models are reported. Dose-response analysis o...


More Articles

Related Compounds

  • O6-Benzylguanine
  • 8-aza-O6-benzylguanine
  • N2-acetyl-O6-benzylguanine
  • O6-[4-(13-amino-2,5,8,11-tetraoxa-tridecyl)-oxymethylbenzyl]guanine
  • O6-Hexanoyl-D-galactose
  • o6-phenyl-2'-deoxyinosine
  • 6-fluoro-2,3-dihydro-1H-indole-2-carboxylic acid
  • tert-butyl N-[2-amino-1-(6-methoxypyridin-2-yl)ethyl]carbamate
  • N-[3-amino-5-(aminomethyl)phenyl]acetamide
  • 2-Cyano-4,5-dihydroxybenzoic acid
  • 4-(Morpholine-4-sulfonyl)-piperazine-1-carboxylic acid tert-butyl ester
  • (3S)-3-{[(benzyloxy)carbonyl]amino}-3-(6-methoxypyridin-2-yl)propanoic acid
  • 3-Isopropoxy-5-(4-(methylsulfonyl)phenoxy)benzimidamide
  • (3R)-3-{[(benzyloxy)carbonyl]amino}-3-(6-methoxypyridin-2-yl)propanoic acid
  • 1-[3-(Azetidin-3-yl)quinoxalin-2-yl]piperidin-4-ol;hydrochloride
  • Ethyl 2-amino-3-hydroxy-3-(6-methoxypyridin-2-yl)propanoate
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