Stattic

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Names

[ CAS No. ]:
19983-44-9

[ Name ]:
Stattic

[Synonym ]:
6-Nitro-benzo<b>thiophen-1,1-dioxid
6-nitro-benzo[b]thiophene-1,1-dioxide
Benzo[b]thiophene, 6-nitro-, 1,1-dioxide
6-nitro-1H-1λ-benzo[b]thiophene-1,1-dione
6-nitro-1
STAT3 Inhibitor V,Stattic
Benzo[b]thiophene,6-nitro-,1,1-dioxide
6-Nitrobenzo[b]thiophene-1,1-dioxide,Stat three inhibitory compound
6-Nitro-1-benzothiophene 1,1-dioxide
6-nitro-1-benzothiophene-1,1-dioxide
Stattic
Stat three inhibitory compound

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
461.1±45.0 °C at 760 mmHg

[ Melting Point ]:
184ºC

[ Molecular Formula ]:
C8H5NO4S

[ Molecular Weight ]:
211.195

[ Flash Point ]:
232.6±28.7 °C

[ Exact Mass ]:
210.993927

[ PSA ]:
88.34000

[ LogP ]:
1.31

[ Appearance of Characters ]:
white to beige

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.671

[ Storage condition ]:
Store at +4°C

[ Water Solubility ]:
DMSO: >20mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
26-36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Benzo[b]thiophene-1,1-dioxide
  • 6-nitro-1,1-dioxo-1λ6-benzo[b]thiophen-5-ylamine
  • N-(1,1-dioxo-1λ6-benzo[b]thiophen-5-yl)-acetamide
  • N-(6-nitro-1,1-dioxo-1λ6-benzo[b]thiophen-5-yl)-acetamide
  • Thianaphthene
  • nitric acid

DownStream

  • 6-Amino-2,3-dihydrobenzo[b]thiophene 1,1-dioxide
  • 6-AMINO-1H-1LAMBDA-6-BENZO[B]THIOPHENE-1,1-DIONE
  • 2,3-dihydro-1-benzothiophen-6-amine

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

6-Mercaptopurine reduces macrophage activation and gut epithelium proliferation through inhibition of GTPase Rac1.

Inflamm. Bowel Dis. 20(9) , 1487-95, (2014)

Inflammatory bowel disease is characterized by chronic intestinal inflammation. Azathioprine and its metabolite 6-mercaptopurine (6-MP) are effective immunosuppressive drugs that are widely used in pa...

Cigarette smoke-induced MMP2 and MMP9 secretion from aortic vascular smooth cells is mediated via the Jak/Stat pathway.

Hum. Pathol. 46(2) , 284-94, (2015)

It is hypothesized that cigarette smoke may increase MMP2 and MMP9 secretion through Jak/Stat pathway in the aorta, thereby facilitating abdominal aortic aneurysm (AAA) formation/progression in smoker...

Reduction of RKIP expression promotes nasopharyngeal carcinoma invasion and metastasis by activating Stat3 signaling.

Oncotarget 6 , 16422-36, (2015)

The role and underlying mechanism of Raf kinase inhibitory protein (RKIP) in nasopharyngeal carcinoma (NPC) metastasis remain unclear. Here, we showed that RKIP was downregulated in the NPC with high ...


More Articles

Related Compounds

  • 2-cyclohexyl-N-{1-[1-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-3-methyl-1H-pyrazol-5-yl}acetamide
  • 2-cyclopentyl-N-(1-(1-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-3-methyl-1H-pyrazol-5-yl)acetamide
  • N-(1-(1-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-3-methyl-1H-pyrazol-5-yl)-3-methoxybenzamide
  • 3-bromo-N-{1-[1-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-3-methyl-1H-pyrazol-5-yl}benzamide
  • 2-chloro-6-fluoro-N-(1-(1-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-3-methyl-1H-pyrazol-5-yl)benzamide
  • N-{1-[1-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-3-methyl-1H-pyrazol-5-yl}-2-(3-methoxyphenoxy)acetamide
  • N-(1-(1-(2,3-dimethylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-3-methyl-1H-pyrazol-5-yl)-2-(thiophen-2-yl)acetamide
  • 3-(2-Hydroxyphenyl)-3-phenylindolin-2-one
  • 2-Bromo-3-butylpyridine
  • 3-cyclohexyl-N-{1-[1-(2,4-dimethylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-3-methyl-1H-pyrazol-5-yl}propanamide
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